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Small Clinical Trial Examines Drug's Ability To Reduce HIV In Body
In the first human trial of GlaxoSmithKline"s (GSK) experimental HIV drug S/GSK1349572, the drug was able to reduce HIV to undetectable levels in 70 percent of the 35 patients taking the treatment for 10 days, according to findings presented at the International AIDS Society"s conference in Cape Town, South Africa, Bloomberg reports. The drug decreased the virus in the body "without the signs of resistance linked to treatments from" Merck"s Isentress and Gilead Sciences" Elvitegravir, according to Bloomberg. GSK will begin a larger trial of the drug this month, Sherene Min, the director of clinical pharmacology discovery medicine for GSK, said. Michael Saag, director of the Center for AIDS Research at the University of Alabama, who is not affiliated with the study, said the scale of viral reduction was "spectacular," adding, "In 10 days to go to undetectable is pretty strong. This thing"s working" (Bennett, 7/21).
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5-Year Study Published In Diabetologia Demonstrated Long-Term Safety Of Lantus(R) Compared To NPH
Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) announced that the results of the long-term, 5-year study of Lantus(R) (insulin glargine [rDNA] injection) versus NPH insulin on progression of retinopathy in patients with type 2 diabetes, published on-line in Diabetologia (DOI 10.1007/s00125-009-1415-7) showed similar effects on retinopathy and overall safety in the two treatment groups. This is the longest controlled study ever reported using insulin glargine.
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Team Uncovers The Molecular Basis For The Regulation Of Blood Clotting
By applying cutting-edge techniques in single-molecule manipulation, researchers at Harvard University have uncovered a fundamental feedback mechanism that the body uses to regulate the clotting of blood. The finding, which could lead to a new physical, quantitative, and predictive model of how the body works to respond to injury, has implications for the treatment of bleeding disorders.
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Acidic Drinks Worse For Teeth Than Whitening

With the increasing popularity of whitening one"s teeth, researchers at the Eastman Institute for Oral Health, part of the University of Rochester Medical Center, set out to learn if there are negative effects on the tooth from using whitening products. Eastman Institute"s YanFang Ren, DDS, PhD, and his team determined that the effects of 6 percent hydrogen peroxide, the common ingredient in professional and over-the-counter whitening products, are insignificant compared to acidic fruit juices. Orange juice markedly decreased hardness and increased roughness of tooth enamel. Unlike ever before, researchers were able to see extensive surface detail thanks to a new focus-variation vertical scanning microscope. "The acid is so strong that the tooth is literally washed away," said Ren, whose findings were recently published in Journal of Dentistry. "The orange juice decreased enamel hardness by 84 percent." No significant change in hardness or surface enamel was found from whitening. Weakened and eroded enamel may speed up the wear of the tooth and increase the risk for tooth decay to quickly develop and spread. "Most soft drinks, including sodas and fruit juices, are acidic in nature," Ren said. "Our studies demonstrated that the orange juice, as an example, can potentially cause significant erosion of teeth." It"s long been known that juice and sodas have high acid content, and can negatively affect enamel hardness. "There are also some studies that showed whitening can affect the hardness of dental enamel, but until now, nobody had compared the two," Ren explained. "This study allowed us to understand the effect of whitening on enamel relative to the effect of a daily dietary activity, such as drinking juices. "It"s potentially a very serious problem for people who drink sodas and fruit juices daily," said Ren, who added that dental researchers nationwide are increasingly studying tooth erosion, and are investing significant res into possible preventions and treatments. "We do not yet have an effective tool to avert the erosive effects, although there are early indications that higher levels of fluoride may help slow down the erosion." A Texas-based company, Beyond Dental and Health, sponsored the trial in part by providing the 6 percent hydrogen peroxide. In the meantime, Ren advises that consumers be aware of the acidic nature of beverages, including sodas, fruit juices, sports and energy drinks. The longer teeth are in contact with the acidic drinks, the more severe the erosion will be. People who sip their drinks slowly over 20 minutes are more likely to have tooth erosion than those who finish a drink quickly. It"s also very important to keep good oral hygiene practices, Ren added, by brushing twice daily with fluoride toothpaste, and see a dentist for a fluoride treatment at least once a year if you are at risk. Karen Black University of Rochester Medical Center


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