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Soaring Summer Temperatures Spell Danger: What To Do To Protect Yourself
From the west to east coast, Americans are experiencing record-breaking temperatures. Some states are reporting triple-digit numbers and the heat has been the cause of several reported deaths. "Children and the elderly are considered the most vulnerable population. It is harder for their bodies to respond to these high temperatures," said Richard N. Bradley, M.D., associate professor of emergency medicine and chief of EMS and disaster medicine at The University of Texas Medical School at Houston.
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Support For Health Overhaul Slipping
A USA Today/Gallup Poll found that "most Americans say it"s important to overhaul health care this year," but "they are less enthusiastic about some of the proposals to pay for it," USA Today reports. "And while a majority say controlling costs should be the legislation"s top goal, more than nine in 10 oppose limits on getting whatever tests or treatments they and their doctors think are necessary." But some good news for President Obama: "A third of those surveyed say they trust him and congressional Democrats most when it comes to changing health care, compared with 10% who choose congressional Republicans. Another 45% trust doctors and hospitals the most."
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Advance In Detecting Melamine-adulterated Food
Researchers in Indiana are reporting an advance toward faster, more sensitive tests for detecting melamine, the substance that killed at least 6 children and sickened 300,000 children in China who drank milk and infant formula adulterated with the substance. The improved tests may ease global concerns about food safety, the researchers say. Their report is scheduled for the May 27 issue of ACS" Journal of Agricultural and Food Chemistry, a bi-weekly publication.
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Aphios Announces Presentation Of Phase II/III Clinical Trial Data On Zindol(R) For Cancer Chemotherapy Induced Nausea

Aphios Corporation announced that the results of a Phase II/III clinical trial of Zindol® for cancer chemotherapy induced nausea will be presented at the 45th Annual Meeting of the American Society of Clinical Oncology (ASCO) being held from May 29 to June 02, 2009 in Orlando, FL. Zindol® is an enhanced ginger product. Despite the widespread use of the 5-HT3 receptor antagonist antiemetics, post-chemotherapy nausea and vomiting continue to be reported by up to 70% of patients receiving chemotherapy. Furthermore, these antiemetics have been associated with significant adverse effects, such as sedation, extra-pyramidal side effects and hypotension (associated with dopamine antagonists), as well as headache, diarrhea or constipation. A desirable attribute in any substitute or additional antiemetic medication is both efficacy and the absence of clinically significant adverse effects. Zindol® is an enhanced ginger product that is standardized by the bioactive constituents of ginger, gingerols and shogaols. Aphios" scientists and engineers utilized a proprietary polarity-guided SuperFluids™ CXF fractionation technology to establish conditions for the isolation of the active ingredients of Zindol®. The technology was then scaled-up for producing large quantities of the active ingredients utilizing patented SuperFluids™ CXP manufacturing technologies. The enhanced ginger concentrate was then formulated to achieve a specific concentration of ginger bioactives with all-natural liquid excipients designed to maximize stability and bioavailability of bioactive constituents, and encapsulated in gel capsules (LiCaps®) by Capsugel, Inc., a Pfizer subsidiary. Researchers at the University of Rochester Medical School conducted a multi-site, Phase II/III randomized, placebo-controlled, double-blind clinical trial to assess the efficacy of Zindol® (ginger capsules) for chemotherapy-related nausea in 644 cancer patients. Cancer patients who experienced nausea were randomized into four arms: placebo and 3 dose-escalation arms taking ginger capsules equivalent to 0.5, 1.0 and 1.5 grams ginger. All patients received 5-HT3 receptor antagonist antiemetics on Day 1 of all cycles. Data from the clinical trial indicates that all ginger doses significantly reduced nausea with the middle and lowest doses giving the best results. Ginger caused no side effects in this study, but patients should consult with their physicians before use. The results of the clinical trial study entitled "Ginger for chemotherapy-related nausea in cancer patients: A URCC CCOP randomized, double-blind, placebo-controlled clinical trial of 644 cancer patients," will be orally presented and discussed on Saturday, May 30, 2009 from 1:00 to 4:00 p.m. in the Patient and Survivor Care session (Level 2, West Hall F5) of ASCO, Orlando, FL. Aphios Corporation


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