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San Francisco Chronicle Profiles U.S. Global AIDS Coordinator
"Dr. Eric Goosby wasted no time starting his new job as the U.S. global AIDS coordinator. He flew from the Bay Area to Geneva hours after his confirmation by the Senate and was sworn in when he landed ò€¦ The ambassador is approaching his post with the urgency of a clinician who has spent more than 25 years fighting the disease," the San Francisco Chronicle writes.
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BioElectronics Is Filing For 510(k) Clearance With FDA For Its AllayTM Product
BioElectronics Corp. (PINKSHEETS: BIEL), the maker of inexpensive, disposable drug-free anti-inflammatory devices, announced it is filing an application with the U.S. Food and Drug Administration (FDA) for 510(k) clearance to market its Allay™ Menstrual Pain Relief Patch product. The filing follows a very successful double blinded, placebo controlled clinical trial in which 71% of women in the active group reported either complete elimination or a reduction in their typical menstrual pain symptoms, with 49% showing at least a 50% reduction in pain associated with dysmenorrhea.
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Need Something? Talk To My Right Ear!
We humans prefer to be addressed in our right ear and are more likely to perform a task when we receive the request in our right ear rather than our left. In a series of three studies, looking at ear preference in communication between humans, Dr. Luca Tommasi and Daniele Marzoli from the University "Gabriele d"Annunzio" in Chieti, Italy, show that a natural side bias, depending on hemispheric asymmetry in the brain, manifests itself in everyday human behavior. Their findings were just published online in Springer"s journal Naturwissenschaften.
Nutrition

Blood-Borne Molecule Helps Regulate Blood-Vessel Integrity

Although maintaining the integrity of blood vessel walls is essential for life, well-controlled temporary leakage of blood contents through the walls of blood vessels into the tissues is a hallmark of inflammation. Although the molecule S1P is known to act on the cells that line blood vessels (endothelial cells) to regulate the permeability of blood vessel walls, the in vivo of SIP in this process remains unknown, and whether it has a role in inflammation has not been determined. In a new study, Shaun Coughlin and colleagues, at UCSF, San Francisco, have shed light on these issues, revealing that mice that lack S1P selectively in plasma (the liquid component of blood) have increased leakage from the blood vessels in response to a variety of stimuli, including inflammatory ones. As the leakage was reversed by treatment with either S1P-containing red blood cells or an agonist for the protein to which SIP binds, the authors conclude that S1P in the blood regulates blood-vessel integrity and prevents potentially lethal decreases in blood volume after exposure to leak-inducing stimuli. TITLE: Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice AUTHOR: Shaun R. Coughlin University of California, San Francisco, San Francisco, USA. View the PDF of this article at: https://www.the-jci.org/article.php?id=38575 Karen Honey Journal of Clinical Investigation JCI online early table of contents: June 15, 2009


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