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Cougar Biotechnology Announces Successful Completion Of Johnson & Johnson's Initial Tender Offer And Commencement Of Subsequent Offering Period
Cougar Biotechnology, Inc. (NASDAQ: CGRB) announced today that the initial offering period of Johnson & Johnson"s (NYSE: JNJ) tender offer for all the outstanding shares of Cougar common stock expired at midnight (Eastern time) on July 2, 2009. The offer was conducted through a wholly-owned subsidiary of Johnson & Johnson named Kite Merger Sub, Inc.
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CPAP Adherence: Problem Solving And Coping Styles
According to a research abstract presented on June 8, at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, active problem solving strategies are associated with successful use of continuous positive airway pressure (CPAP) therapy for the treatment of obstructive sleep apnea (OSA).
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IQ Explains Some Of The Difference In Heart Disease Between People Of High And Low Socio-economic Status
A unique study looking at the difference in cardiovascular disease (heart disease and stroke) and life expectancy between people of high and low socio-economic status has found that a person"s IQ may have a role to play.
Oncology

Can Tribble 3 Can Induce Non-Alcoholic Fatty Liver Disease?

Three pseudo kinases of the Tribbles family have been recently recognized, which include TRB1, TRB2 and TRB3. Recent research has found that the expression of hepatic TRB3 increased in a rat model of diabetes. TRB3 could block the insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance. This research, lead by Dr. Yu-Gang Wang and his colleagues in the Department of Gastroenterology, Shanghai Changning Central Hospital, China, used real-time fluorescent quantitative reverse transcription-polymerase chain reaction technology and Western blotting analysis to study the protein expression of TRB3mRNA, Akt and phosphorylation protein kinase B during the progression of NAFLD. The expression level of TRB3mRNA in NAFLD rats was significantly higher than in normal controls. Also, the expression levels of Akt and p-Akt-Thr308 in NAFLD rats was significantly lower than the control group. Since TRB3 can block insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance, it may be an important factor in the occurrence and development of NAFLD. This study provides an experimental basis for future studies on the role of TRB3 in NAFLD. The control of the expression level of TRB3 in liver may become a new target for NAFLD therapy. Reference: Wang YG, Shi M, Wang T, Shi T, Wei J, Wang N, Chen XM. Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease. World J Gastroenterol 2009; 15(19): 2329-2335 Correspondence to: Dr. Xi-Mei Chen, Department of Gastroenterology, Tongji Hospital of Tongji University, Shanghai 200065, China. Jian-Xia Cheng World Journal of Gastroenterology


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