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Gene Signature Helps Predict Breast Cancer Prognosis
Vanderbilt-Ingram Cancer Center researchers have uncovered a gene signature that may help predict clinical outcomes in certain types of breast cancer.
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Research To Investigate The Clinical And Cost-effectiveness Of Bone Anchored Hearing Aids
New research commissioned by the National Institute for Health Research Health Technology Assessment (NIHR HTA) programme will assess the clinical and cost-effectiveness of bone anchored hearing aids (BAHAs) for people who are bilaterally deaf (deaf in both ears). Hearing impairment is the most common sensory deficit and it is estimated that there are approximately 688,000 severely to profoundly deaf adults in the UK. According to evidence given to the House of Commons Health Committee, the NHS tariff puts the cost per person of conventional hearing aid provision from appointment and clinic time to use of equipment at about ÷£270. The price of a working BAHA per patient is estimated to be at least ÷£4500.
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Supreme Court Rules Pensions Need Not Include Maternity Leave Taken Prior To Pregnancy Discrimination Act
The Supreme Court on Monday in a 7-2 decision ruled that employers are not required to award women credit toward pension benefits for maternity leave taken before Congress passed the 1978 Pregnancy Discrimination Act, which states that pregnancy should be treated like other temporary disabilities, the New York Times reports. The majority opinion stated that the 1978 law, which made pregnancy-related discrimination a form of sex discrimination, was not retroactive; therefore, employers were not required to adjust the pension calculations for these women. The case decided Monday -- AT&T v. Hulteen -- involved four women who had taken maternity leaves before 1978, when it was legal for employers to treat pregnancy leave differently from other types of disability leave. In the majority opinion, Justice David Souter wrote that the women are not entitled to full credit for their pregnancy leaves and will therefore receive smaller pensions, the Times reports. Souter was joined in the majority by Chief Justice John Roberts and Justices John Paul Stevens, Antonin Scalia, Anthony Kennedy, Clarence Thomas and Samuel Alito. Justices Ruth Bader Ginsburg and Stephen Breyer dissented. Souter"s ruling was based in great part on a 1976 Supreme Court ruling, General Electric v. Gilbert, which found that policies treating pregnancy leave worse than other types of disability leaves did not amount to sex discrimination (Liptak, New York Times, 5/19). Congress swiftly overruled Gilbert by passing the Pregnancy Discrimination Act (Egelko, San Francisco Chronicle, 5/19). Ginsburg in the dissent wrote that the court had "erred egregiously" in Gilbert, which she said advanced the "strange notion that a benefits classification excluding" pregnant women is not based on sex "because other women are among the favored class ("non-pregnant persons")." Ginsburg said that in passing the Pregnancy Discrimination Act, Congress did not intend to continue reducing women"s compensation, including pension benefits, "attributable to their placement on pregnancy leave," adding that the women involved in the case will receive smaller pensions than their colleagues for the rest of their lives (New York Times, 5/19). "[A]ttitudes about pregnancy and childbirth ... have sustained pervasive, often law-sanctioned, restrictions on a woman"s place among paid workers and active citizens," Ginsburg said (Biskupic, USA Today, 5/19).ImpactJudith Kurtz, a plaintiffs" attorney in the case, said the ruling will affect thousands of women across the country, nearly all of them in the telecommunications industry. Debra Ness, president of the National Partnership for Women and Families, said that the decision is "a painful and serious blow to America"s working women and the families who rely on their retirement benefits" (San Francisco Chronicle, 5/19). Ness said that the decision "forces women to pay a high price today because their employers discriminated yesterday" (Holland, AP/Google.com, 5/18). She added, "In the current economic climate, women and their families cannot afford to see their retirement benefits kept lower by discriminatory workplace policies that should have been remedied decades ago" (Mears, CNN.com, 5/18). Some women"s rights advocates said the ruling is comparable to the pay discrimination decision against Lilly Ledbetter in 2007. Marcia Greenberger of the National Women"s Law Center said the decision was "an all-too-timely reminder of the importance of having on the Supreme Court justices who understand the real-world impact of the law" (Savage, Los Angeles Times, 5/19).
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Environmental Cues Control Reproductive Timing And Longevity, University Of Minnesota Study Shows

When humans and animals delay reproduction because food or other res are scarce, they may live longer to increase the impact of reproduction, according to a new study by University of Minnesota researchers published in the June 25 issue of PLoS (Public Library of Science) One. The discovery, which explains why starvation can lead to longer life, has important implications for improving human health and lengthening lifespan. The basic premise is that individuals use environmental cues to predict population declines, causing them to delay reproduction until the decline has occurred, when each offspring will make a bigger contribution to the gene pool. Conversely, if bad times turn to good times and the population is on the verge of a boom, reproducing sooner rather than later will help their genes thrive. "If the population is decreasing, future kids make a bigger splash in the gene pool than current kids," explains Will Ratcliff, a College of Biological Sciences graduate student who came up with the idea for the study. "So, if there are tradeoffs between current and future reproduction, delaying reproduction can be a good idea, even if it reduces the number of kids you have during your lifetime." Fluctuations in testosterone levels provide an example of how the environment and organisms interact to guide reproduction, explains R. Ford Denison, adjunct professor in the College of Biological Sciences and Ratcliff"s adviser. Testosterone suppresses the immune system. So when environmental conditions trigger high levels, reproduction is high but longevity drops. Environmental factors also control the age of menarche. In African countries with chronic food shortages, girls experience menarche much later than in the U.S., where rich diets trigger early menarche. Food scarcity is a signal that population is likely to decline, so reproduction is delayed, while an abundance of rich food signals an increase, causing reproductive age to drop. "Our hypothesis may explain hormesis, the mysterious health benefits of low doses of toxins - including those that plants like broccoli make to defend themselves from insects," says Denison. " When their usual foods are scarce, organisms turn to plants containing chemicals that can suppress reproduction and consequently increase longevity "These toxins may be abundant in "famine foods" that are eaten only when meat and fruit are not available" Denison adds. Graduate student Peter Hawthorne and professor Michael Travisano also co-authored the paper. All four co-authors are in the College of Biological Sciences" Department of Ecology, Evolution and Behavior. Patty Mattern University of Minnesota


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