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Combination Therapy For Type 2 Diabetes With Rosiglitazone (RECORD Study) Shows No Increase Of Cardiovascular Disease Or Death
The results of the RECORD study are reported in an article published Online First and in a future edition of The Lancet. The findings are presented at the same time at the American Diabetes Association (ADA) meeting in New Orleans, USA. They indicate that the use of rosiglitazone (Avandia) together with regular diabetes treatments (metformin or a sulfonylurea) to reduce blood glucose in type 2 diabetics does not raise the risk of cardiovascular disease or death. On the other hand, the research establishes that using rosiglitazone multiplies by more than two the risk of heart failure, and increases the risk of fracture, mostly in women.
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International Society For Pharmaceutical Engineering Asks Pharma Professionals To Share Their Knowledge
ISPE, a global not-for-profit association of 25,000 pharmaceutical science and manufacturing professionals, announced that it is accepting proposals from pharmaceutical professionals for content that can be included in a variety of its educational res.
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Costliest Medicare Markets In Florida, New York, California
U.S. News & World Report examines cost, frequency, and outcomes studies on Medicare patients from the Dartmouth Institute for Health Policy and Clinical Practice : "The Dartmouth research is particularly relevant to older Americans because it is based to a large extent on Medicare data, involving patients ages 65 and older. The 2008 atlas, in particular, paints a devastating portrait of Medicare treatments based on an extensive study of Medicare recipients who died from one or more of nine chronic illnesses. Not only are chronic illnesses very expensive to treat, but they"re also the cause of most deaths in the United States. According to the 2008 atlas: More than 90 million Americans live with at least one chronic illness, and 7 out of 10 Americans die from chronic disease. Among the population that receives Medicare, the toll is even greater: About 9 out of 10 deaths are associated with just nine chronic illnesses: congestive heart failure, chronic lung disease, cancer, coronary artery disease, renal failure, peripheral vascular disease, diabetes, chronic liver disease, and dementia."
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Lifelong Cancer Risk For Patients Treated For Childhood Cancer

Childhood cancer survivors have a persistent and high risk for a second primary cancer throughout their lives, according to a new study published in the May 26 online issue of the Journal of the National Cancer Institute. Previous studies established that second primary cancer risk after treatment in childhood is higher than that in the general population, but follow-up was restricted to a few decades and the incidence in long-term survivors was rarely investigated. This study presents data for incidence of second cancers among childhood cancer patients in the Nordic countries over a full age range, from birth to age 79. In the study, JÃñrgen H. Olsen, M.D., of the Institute of Cancer Epidemiology, Danish Cancer Society, in Copenhagen, Denmark, and colleagues studied a cohort of 47,697 people who were diagnosed with cancer prior to the age of 20, from 1943 to 2005. Members of the cohort were followed for subsequent primary cancers listed in registries, and the age-specific risk pattern of the survivors was compared with that of the national populations using country and sex standardized incidence ratios (SIRs). The researchers found that the observed incidence rate of new primary cancers was higher than the expected rates, and the relative risk of second primary cancers was statistically significantly increased in all age groups. A total of 1,180 second primary cancers were observed in 1,088 persons, yielding a SIR of 3.3, with the brain as the most common site. They also found that the relative risk for second primary cancers in male survivors was statistically significantly higher than in female survivors. "This study quantified long-term temporal patterns of increased risk of cancer at specific sites in survivors of childhood cancer," the authors write. "The results may be useful in the screening and care of these individuals." Citation: Olsen et al. Lifelong Cancer Incidence in 47 697 Patients Treated for Childhood Cancer in the Nordic Countries. J Natl Cancer Inst 2009, 101: 806-813. Steve Graff Journal of the National Cancer Institute


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