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Amyloid Aggregations And Tau Pathology Reflected By Cortical Thickness In The Default Network Of MCI And AD
Alzheimer"s disease patients show a relentless decline in memory over the course of the disease, which is accompanied by both brain atrophy and by characteristic deposits in the brain tissue called amyloid plaques and neurofibrillary tangles. Researchers from the Chinese Academy of Sciences studied a large database, collected in the US, of patients with Alzheimer"s or memory complaints who had MRI scans and had spinal taps to collect cerebrospinal fluid, which is in the brain and spinal chord. By examining the CFS they could measure the amounts of the substances that make p plaques and tangles, and related this to brain atrophy. They found that the amount of plaque and tangle-producing chemicals in the cerebrospinal fluid correlated with brain tissue loss in selective regions of the brain which are typically affected in Alzheimer"s disease. The brains in these regions had thinned out suggesting that brain cells had died. These regions are important for memory and are typically active when the brain is at rest. Using these techniques may ultimately help identify early markers of disease in Alzheimer"s, potentially indicating who is likely to develop Alzheimer"s before memory loss is critical.
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Pharming Receives Agreement On Paediatric Investigation Plan For Rhucin(R) From The EMEA Paediatric Committee
Biotech company Pharming Group NV ("Pharming" or "the Company") (NYSE Euronext: PHARM) today announced that the Paediatric Committee (PDCO) of the European Medicines Agency (EMEA) has adopted an opinion agreeing the paediatric investigation plan (PIP) for Rhucin® (recombinant human C1 inhibitor) in the therapeutic area of immunology-rheumatology transplantation.
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Testosterone Replacement For Men With Low Testosterone Improves Liver Function, Metabolic Syndrome
In middle-aged and older men with low testosterone levels, long-term testosterone replacement therapy greatly improves their fatty liver disease and their risk factors for cardiovascular disease and diabetes, a new study found. The results were presented at The Endocrine Society"s 91st Annual Meeting in Washington, D.C.
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Online Reporting System For Swine Flu Antiviral Side Effects

Suspected side effects to swine flu antiviral medicines can now be reported to the Medicines and Healthcare products Regulatory Agency (MHRA) via a new dedicated webpage (http://www.mhra.gov.uk/swineflu). The online system is based on the highly successful Yellow Card Scheme and is designed to make completing a report quick and easy for the public as well as healthcare professionals. This will assist the MHRA in efficiently monitoring the safety of the swine flu antiviral medicines, Tamiflu and Relenza, as their use increases during the swine flu pandemic. MHRA Director of Vigilance and Risk Management of Medicines, Dr June Raine, said Tamiflu and Relenza are acceptably safe and most people will not suffer any side effects. "Like all medicines, the MHRA keeps the safety of these continually under review and we are keen to let people know there is a new way to tell us of any side effect suspicions. "If someone thinks they may have had a side effect to their medication, they should see their healthcare professional first to check they are okay. They should then report it to the MHRA via the "Swine Flu ADR Portal". "If they are unable to access the Internet, their healthcare provider can send a report on their behalf. "By providing this information, not only are the MHRA able to gain better insights into the safety of medicines, but people can directly contribute to effective medicines regulation." Notes 1. The UK has stockpiled the antiviral medicines Tamiflu and Relenza for management of the swine flu pandemic. 2. The existing Yellow Card Scheme will remain in operation during this time for reporting suspected ADRs to all other medicines. 3. The MHRA has received 20 suspected ADR reports to Tamiflu and no suspected ADR reports to Relenza since the start of the swine flu outbreak. No new risks have been identified. MHRA


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