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No More Test Tubes On Four Feet? EPA Moves Toward Animal-free Toxicity Tests
The U.S. Environmental Protection Agency (EPA) plans to switch to a new generation of animal-free tests for predicting the toxicity of chemicals to humans, according to an article scheduled for the June 22 issue of Chemical & Engineering News, ACS" weekly newsmagazine.
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Amyloid Aggregations And Tau Pathology Reflected By Cortical Thickness In The Default Network Of MCI And AD
Alzheimer"s disease patients show a relentless decline in memory over the course of the disease, which is accompanied by both brain atrophy and by characteristic deposits in the brain tissue called amyloid plaques and neurofibrillary tangles. Researchers from the Chinese Academy of Sciences studied a large database, collected in the US, of patients with Alzheimer"s or memory complaints who had MRI scans and had spinal taps to collect cerebrospinal fluid, which is in the brain and spinal chord. By examining the CFS they could measure the amounts of the substances that make p plaques and tangles, and related this to brain atrophy. They found that the amount of plaque and tangle-producing chemicals in the cerebrospinal fluid correlated with brain tissue loss in selective regions of the brain which are typically affected in Alzheimer"s disease. The brains in these regions had thinned out suggesting that brain cells had died. These regions are important for memory and are typically active when the brain is at rest. Using these techniques may ultimately help identify early markers of disease in Alzheimer"s, potentially indicating who is likely to develop Alzheimer"s before memory loss is critical.
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White House Reassures Drug CEOs: Reimportation Could Be 'Unnecessary'

The Wall Street Journal reports: "Industry representatives met at the White House Tuesday with officials to consider specifics of a cost-saving agreement the industry reached last month with health-care negotiators and to discuss other concerns that the pharmaceutical industry has with the larger health-care overhaul being considered by Congress. As a presidential candidate, President Barack Obama endorsed re-importation, an idea the industry opposes. White House officials have told the industry if the larger health care bill passes, the cost savings will be so great that reimportation will be unnecessary, according to Billy Tauzin, president of the Pharmaceutical Research and Manufacturers of America." Some of the pharmaceutical companies represented at the Tuesday meeting included Merck & Co., Pfizer Inc., Amgen Inc., Abbott Laboratories and AstraZeneca. The Wall Street Journal notes: "Sen. Bernie Sanders, an independent from Vermont, said he disagrees with any move to drop the reimportation idea. He has pushed to import drugs from Canada, where they are cheaper because of price controls" (Mundy, 7/7). Roll Call: "With the White House and the Senate Finance Committee still trying to figure out how to pay for health care reform, the drug industry is trying to solidify its contributions to the effort. Pharmaceutical Research and Manufacturers of America CEO Billy Tauzin and five member- company CEOs went to the White House on Tuesday afternoon to solidify the $80 billion deal they recently struck with the White House and Senate Finance Chairman Max Baucus (D-Mont.) ... The meeting follows reports that the Congressional Budget Office is expected to score the drug companies" deal as less than the advertised $80 billion in savings, according to several health care lobbyists" (Palmer, 7/8). This information was reprinted from kaiserhealthnews.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Health Policy Report, search the archives and sign up for email delivery at kaiserhealthnews.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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