Mental Health
Biophysicists long for an ideal material - something more structured and less sticky than a standard glass surface - to anchor and position individual biomolecules. Gold is an alluring possibility, with its simple chemistry and the ease with which it can be patterned. Unfortunately, gold also tends to be sticky and can be melted by lasers. Now, biophysicists at JILA have made gold more precious than ever - at least as a research tool - by creating nonstick gold surfaces and laser-safe gold nanoposts, a potential boon to laser trapping of biomolecules.
Risk for hepatocellular carcinoma, a primary malignancy of the liver, was statistically significantly higher among women with hepatitis B virus (HBV) infection than among women without the virus, according to a study published online June 17 in the JNCI.
Brian Andrew Tully, Esq., an attorney specializing in elder law, argues against POLST (Physicians" Orders for Life-Sustaining Treatment). In his article "A Counterview: Objections to the POLST Paradigm," which was published in the February 2009 issue ofThe Elder Law Report, Mr. Tully states that POLST gives physicians autonomy in the decision-making process, without having to consult with the patient or the health care proxy.
Oxoid, a world leading microbiology brand, is pleased to announce that the ProSpecT™ range of qualitative enzyme immunoassays has recently been extended to include test kits for Adenovirus, Astrovirus, Clostridium difficile, Campylobacter, Cryptosporidium, Entamoeba histolytica, Giardia, Giardia/Cryptosporidium, Rotavirus, Shiga Toxin Escherichia coli.
The National Patient Safety Agency (NPSA) is calling on health practitioners and staff across England and Wales to follow recommendations, issued recently, to improve patient safety for children and young people.
ProFibrix B.V. announced the start of the company"s
Gastroenteritis means irritation and inflammation of the gastrointestinal tract, which includes the stomach and small and large intestines. The condition is usually due to bacteria, food poisoning, parasites, or viruses, and it often results in diarrhea, abdominal pain, nausea, and vomiting. Gastroenteritis is commonly called gastric flu or stomach flu although it has no relation to the influenza virus.
According to a report issued, drug safety leaders in pharmaceutical and biotechnology companies recognise the need to increase res, either internally or through partnerships, to comply with the safety regulations recently issued by the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMEA). The report - Safety First: The Impact of New Regulations on Clinical Development - is based on a survey of 140 industry safety specialists, including heads of medical, drug safety, pharmacovigilance, and regulatory departments within large and mid-sized pharmaceutical companies and biotech firms. The survey found that more than three-quarters (77%) of respondents believe that new safety regulations have had a considerable impact on the industry as companies implement drug safety regulations throughout the clinical development process.
Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in the field of human gene therapy, announced today new data showing that a one-time administration of its lead product GlyberaTM results in significant long-term health benefits. Long-term follow-up data from two clinical trials show that one administration with GlyberaTM brings significant and clinically important reduction in acute pancreatitis in lipoprotein lipase deficient patients. Recurrent acute pancreatitis is the most debilitating complication of lipoprotein lipase deficiency (LPLD) and is associated with significant morbidity and mortality. These data were presented at the International Symposium on Atherosclerosis in Boston, one on the most prestigious conferences on arterial disease well-attended by expert physicians.
U.S. Representatives Rep. Artur Davis (D-AL), Steve Israel (D-NY) and Mary Jo Kilroy (D-OH) have introduced H.R. 2872, the Medicare Quality Cancer Care Demonstration Act of 2009. H.R. 2872 is a bill that will authorize Congress to direct the Centers for Medicare & Medicaid Services (CMS) to implement the Quality Cancer Care Demonstration (QCCD) project.
A new landmark collaboration between the Global Alliance for TB Drug Development (TB Alliance), a not-for-profit, product development partnership, and Tibotec Inc., (Tibotec), a global pharmaceutical company, has been announced at the Pacific Health Summit in response to the urgent need to accelerate the discovery and development of new drugs to fight tuberculosis (TB).
Provectus Pharmaceuticals, Inc. (OTC BB: PVCT), a development-stage oncology and dermatology biopharmaceutical company has completed patient accrual and initial PV-10 treatment in its Phase 2 trial of PV-10 for metastatic melanoma. The study involved treatment of 80 subjects with Stage III or Stage IV metastatic melanoma.
Billing claims from health insurance companies can provide insights on the long-term health of kidney transplant patients, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The findings indicate that valuable health information can be obtained by analyzing medical insurers" reimbursement documents, a process that is much simpler and cheaper than many other forms of clinical investigation.
Omega-3 fatty acids found in fatty fish such as tuna and salmon may protect against progression of age-related macular degeneration (AMD), but the benefits appear to depend on the stage of disease and whether certain supplements are taken, report researchers at the Laboratory for Nutrition and Vision Research (LNVR), Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University.
Osmetech (LSE:OMH) announced that it has submitted a request to the US FDA for Emergency Use Authorization (EUA) for its Respiratory Pathogen Test Panel test to be used to screen for the swine flu virus.
Queen"s University Belfast academics have helped develop an antioxidant supplement which may slow down sight loss in elderly people.
NEARLY two thirds of the British public are neglecting their eyesight, according to the results of a shock survey released today.
Health officials said on Thursday that it looks like the novel H1N1 swine flu virus will continue to spread in the US through the summer months,
The American Institute for Cancer Research (AICR) is launching a new campaign in partnership with Giant Food. The campaign, called Shop for Health, Eat for Life, will run in all Giant food stores from June 19 to July 2, 2009.
Thousands of unregistered Rohingya refugees living in the Kutupalong makeshift camp, Bangladesh, are being forcibly displaced from their homes, in an act of intimidation and abuse by the local authorities. The international medical organization Doctors Without Border/Mç©decins Sans Frontiç¨res (MSF) has treated numerous people for injuries, of which the majority were women and children. Furthermore, MSF has witnessed countless destroyed homes and heard many reports of people being warned to remove their own shelters or face the consequences.
The Honourable Leona Aglukkaq, Minister of Health, and Dr. Chen Zhu, Minister of Health for the People"s Republic of China, today signed a Plan of Action for continued cooperation between the two countries on health priorities of mutual concern. The signing ceremony followed discussions among senior Canadian and Chinese health officials and experts on a range of health issues, including strengthening and reform of health-care systems, primary health care and food safety.
NHS Barking and Dagenham and HIV and sexual health charity Terrence Higgins Trust (THT) have achieved a national target by encouraging over 17% of under-25s in the region to test for the sexually transmitted infection (STI) chlamydia. To tackle chlamydia in the area, more young people need to come forward for testing and continue testing on a regular basis - the target for 2009/2010 is 25%.
Our ability to form long-term memories depends on cells in the brain making strong connections with each other. Yet while it"s not well understood how those connections are made, lost or changed, the process is known to involve the movement of the AMPA receptor protein to and from those neuronal connections.
A move from analogue to DAB radio may leave people with sight problems left out of Britain"s digital revolution if steps are not taken to assist in the switchover, laid out today in the communications Minister Lord Carter"s Digital Britain report.
The drugmaker Sanofi-Aventis will donate millions of doses of a vaccine that offers protection against the H1N1 (swine flu) virus to the WHO once the vaccine is ready, the company"s chief executive officer announced Tuesday, Reuters reports (Elsner, Reuters, 6/17). The AP/Google.com writes, "Exceptional times require exceptional responses. We need to act responsibly and we all have to play our part," Sanofi CEO Christopher Viehbacher said in a statement released during the Pacific Health Summit in Seattle. "This flexible donation aims to help the WHO address the needs of these most vulnerable populations," he said.
The Guardian examines the recent U.S. commitment to continue support for the development of Nigeria"s health and education sector by Anne Fleuret, Nigeria"s acting mission director of USAID. At the conclusion of two USAID-funded projects in Nigeria, Fleuret said the HIV/AIDS programs were created six years ago "to empower communities." She added, "We envisioned so many things and we have substantially achieved that vision. We have provided support from the community level to the legislative level."
Supreme Court nominee Sonia Sotomayor in conversations with senators has indicated her support for Roe v. Wade, even if she has not explicitly stated that she supports abortion rights, the AP/Yahoo! News reports. According to the AP/Yahoo! News, Sotomayor is "following a time-honored tradition" among nominees of assuring senators that she will not aim to impose a certain agenda, while also avoiding firm commitments on how she might rule on certain issues -- such as abortion rights -- if they come before the court. In questioning Sotomayor, senators hope to obtain assurances that she will honor certain precedents, such as Roe, which allows them to justify their votes for her to their constituents, the AP/Yahoo! News reports. Doug Kendall of the Constitutional Accountability Center said, "There"s always a bit of a parlor game that develops in terms of what precisely words said by nominees mean."Because Sotomayor has never directly ruled on the key issues in Roe, advocates on both sides of the abortion-rights debate have speculated over her views on constitutional privacy rights. White House spokesperson Robert Gibbs has said that President Obama and Sotomayor discussed her "views on unenumerated rights in the Constitution and the theory of settled law." The AP/Yahoo! News reports that Gibbs" comments indicate that Sotomayor would be unlikely to overturn Roe, which supporters consider "settled law." Sens. Dianne Feinstein (D-Calif.) and Benjamin Cardin (D-Md.), both of whom support abortion rights, said they spoke with Sotomayor about her position during private meetings and were pleased with her answers. Feinstein said that Sotomayor is "a woman who is well-steeped in the law and well-steeped in precedent, and I believe that she has a real respect for precedent." Sen. Jim DeMint (R-S.C.), an opponent of abortion rights, said that when he privately asked Sotomayor whether she believed a fetus should have any constitutional rights, she responded that she had never considered the issue (Hirschfeld Davis, AP/Yahoo! News, 6/18).
A recent study from Columbia University"s Mailman School of Public Health shows that since 2003, there has been a 10% decrease in contraception use among teenagers, while their level of sexual activity has not changed, a New York Times editorial states. From 1991 to 2003, increased use of contraceptives among teens was a significant factor in declining rates of teenage pregnancy, the editorial says. According to the study"s authors, the decrease in contraception use since 2003 is consistent with recent increases in teen birth rates. According to the editorial, the study"s authors suggest a "link between the shift in use of contraception and one of former President George W. Bush"s great social-policy follies: highly restrictive abstinence-only sex education programs that deny young people information about sexually transmitted diseases, contraceptives and pregnancy." The editorial adds, "To the extent that these programs even mention condoms, typically it is to disparage their effectiveness." In response to "mounting evidence of the program"s danger as a public health strategy," many states have forgone federal abstinence-only funds, the editorial says. As part of his budget proposal, President Obama has called for redirecting some abstinence-only funds and additional money to a new teen pregnancy prevention initiative that stresses comprehensive sex education. The editorial concludes that this "science-based effort to protect the health of young people" and reduce the number of unintended pregnancies "should win support from lawmakers on both sides of the aisle -- and both sides of the abortion divide" (New York Times, 6/18).
The National Infertility Awareness Campaign (NIAC) welcomed the document "Standardising Access Criteria to NHS Fertility Treatment"1 produced by Infertility Network UK (I N UK) and funded by the Department of Health.
In Los Angeles County, being disabled can cost a year"s income. That"s because the annual cost of in-home care services for seniors living alone is now $319 more than this group"s median income of $17,029.
The Medical Defence Union (MDU) is reminding its GP members about the steps they can take to avoid medication errors when treating children and the importance of learning from errors. The advice follows the publication of the National Patient Safety Agency"s (NPSA) first review of patient safety incidents involving the under 18s reported under the national reporting and learning system (RLS).
Natural Standard Research Collaboration invites researchers to submit articles to Journal of Dietary Supplements (JDS) - an international peer-reviewed forum for original research and review articles that focus on vitamins, minerals, herbs and other substances that make up the multi-billion dollar dietary supplement industry. The journal addresses important issues that meet a broad range of interests - not only in integrative healthcare, but also in academic, regulatory and industrial sectors.
The British Climate Act is flawed and comprised of unrealistic and unobtainable targets, writes US academic Roger A Pielke Jr, in a journal paper published on the 18th June, 2009, in IOP Publishing"s Environmental Research Letters.
The Norwegian biopharmaceutical company Lytix Biopharma and Korean company KAEL-GemVax announced the signing of a collaborative agreement to test lead compounds LTX-315 and GV1001 as a combination therapy for the treatment of cancer.
Congress can help diminish barriers to quality care for people with serious illness, according to Howard Tuch, MD, MS, a spokesperson for the American Academy of Hospice and Palliative Medicine (AAHPM). AAHPM was one of three groups that presented information at a Capitol Hill briefing coordinated by the offices of US Reps. Earl Blumenauer and Charles Boustany, MD, sponsors of legislation (HR 1898) that would provide Medicare coverage for "end of life" care consultations.
Accuray Incorporated (Nasdaq: ARAY), a global leader in the field of radiosurgery, announced that the Turkish Ministry of Health has purchased two CyberKnife(R) Robotic Radiosurgery Systems for installation in Ankara and Istanbul, Turkey.
The American Lung Association released its State of the Air: 2009 Report this month. The 10th annual report states that air pollution has significantly improved in some areas of the country, but major cities still have significant problems with pollutants.
Seattle Genetics, Inc. (NASDAQ:SGEN), announced that it has initiated a phase II clinical trial of SGN-35 for patients with relapsed or refractory systemic anaplastic large cell lymphoma (ALCL). SGN-35 is an antibody-drug conjugate (ADC) that utilizes Seattle Genetics" proprietary technology to empower antibodies by linking them to potent cell-killing drugs.
In light of Air Canada"s decision to follow WestJet"s lead and allow pets to travel in the passenger cabin of airplanes, The Canadian Lung Association today released the following statement:
The Actuarial Profession has published, for consultation, a prototype model to project future mortality rates. The model has been developed in response to the continuation of significant increases in life expectancy since projections were last published by the Profession in 2002.
UroToday.com - Insufficient intake of zinc (Zn) can impair antioxidant defenses and may be an important risk factor in oxidant release, compromising the mechanism of DNA repair, and making the sperm cell highly susceptible to oxidative damage. In the absence of Zn, the possibility of increased oxidative damage exists that would contribute to poor sperm quality. Infertile men and men who smoke are very susceptible to oxidative damage induced by free radicals. In the present study, we hypothesized that major changes in the level of seminal Zn levels are related with low quality of sperm and poor fertilizing capacity.
"The high cost of securing health insurance for all Americans, the top domestic priority of President Obama, has Congressional Democrats scrambling to scale back their proposals or find ways to trim tens of billions of dollars a year from existing health programs," the New York Times reports. Early estimates for the cost of the Senate Finance Committee"s reform proposal are far higher than anticipated, forcing leading senators in charge of shaping the legislation into a holding pattern as they seek lower-cost alternatives. Among the items being considered: ""an automatic mechanism" to reduce the growth of Medicare under an expedited procedure like the one used to close military bases" and a requirement that some employers contribute to the cost of Medicaid or private health insurance for low-wage workers.
The Houston Chronicle reports on a medical philosophy that focuses on providing coordinated care and personal care to older patients, mostly indigent seniors. The paper examines Select Senior Clinic, a Texas facility that ascribes to the medical home concept.
American Lung Association Calls Upon President Obama to Protect Entire Federal Workforce
Just in time for Father"s Day weekend, the Secretary of Health and Human Services Kathleen Sebelius announced a new public service campaign today promoting fatherhood that features a PSA by President Obama. The campaign, sponsored by the department"s Administration for Children and Families and the Advertising Council, can be found at http://www.fatherhood.gov. The public service announcements and supporting campaign materials highlight the critical role fathers play in their children"s lives.
As part of an effort to encourage Staten Island, N.Y., residents to be tested for HIV, the CARE Network, the Black Leadership Commission on AIDS and the City Council"s Communities of Color Faith Initiative, have partnered to launch the "Staten Island HIV Status Check Campaign," the Staten Island Advance reports. "Status Check" postcards that include information on free local HIV testing locations, HIV educational literature and condoms will be distributed by local organizations and businesses as part of the initiative. The goal is to reach the 56 percent of local residents who have never been tested for HIV, Karina Ryan, CARE Network coordinator, said (Slepian, Staten Island Advance, 6/18).
As summer pests are a natural part of the outdoors and typically viewed simply as a nuisance, many believe that they have a full understanding of the risks associated with such. Yet, the National Pest Management Association (NPMA) warns that there are a multitude of myths about summer insects that homeowners subscribe to - most of which wrongly minimize the threats of stinging insects, mosquitoes and ants.
The U.S. Environmental Protection Agency (EPA) plans to switch to a new generation of animal-free tests for predicting the toxicity of chemicals to humans, according to an article scheduled for the June 22 issue of Chemical & Engineering News, ACS" weekly newsmagazine.
It is unethical to stop healthy people from taking methylphenidate (Ritalin) to enhance their mental performance, says John Harris, Professor of Bioethics at the University of Manchester, in an article published on bmj.com today. He adds that society "ought to want [enhancement]" and that "it is not rational to be against human enhancement."
"Moving to a more continuous follow-up approach would have the tremendous advantages of enhancing patient safety, decreasing physician and nurse work load, and allowing health staff to focus on medical emergencies," urged Professor Angelo Auricchio, from the European Heart Rhythm Association (EHRA) and official spokesperson of the European Society of Cardiology (ESC), adding that such systems may have the additional advantage of being more cost effective for health care providers.
MRSA infections that are transmitted between dogs/cats and their human handlers, and vice-versa, are increasing-with infections of the skin, soft-tissue, and surgical infections the most common. This and other bite-related and septic syndromes caused by cats and dogs are discussed in a Review in the July edition of The Lancet Infectious Diseases, written by Dr Richard Oehler, University of South Florida College of Medicine, Tampa, FL, USA, and colleagues.
HHS Secretary Kathleen Sebelius announced that $6 billion in new federal funds will be made available to states and U.S. territories for fiscal year 2009 to provide health care to millions of children across America through their Children"s Health Insurance Programs (CHIP).
The Damon Runyon Cancer Research Foundation, a non-profit organization focused on supporting exceptional early career researchers and innovative cancer research, named 17 new Damon Runyon Fellows at its May 2009 Fellowship Award Committee review. The recipients of this prestigious, three-year award are outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators across the country. The Fellowship is specifically intended to encourage the nation"s most promising young scientists to pursue careers in cancer research by providing them with independent funding ($140,000 each) to work on innovative projects.
Epeius Biotechnologies stuns the medical and scientific communities with a dramatic demonstration of single-agent efficacy with its lead product, Rexin-G, for metastatic cancer. The landmark article (accessible online as of June 16, 2009 in Molecular Therapy, the Official Journal of The American Society of Gene Therapy, documents the results of two related studies using Rexin-G, a tumor-targeted anti-cancer agent designed to seek-out and destroy metastatic cancers that have spread throughout the body, while sparing normal cells and healthy tissues and organs. Following the FDA"s designation of Rexin-G as an Orphan Drug for the treatment of soft tissue sarcoma and osteosarcoma in 2008, the results of these two independent studies represent a major step toward gaining Accelerated Approval of Rexin-G for osteosarcoma in the United States.
In the area of secondary prevention as well - guarding against renewed events in patients who already suffered from a stroke or a TIA - Professor Ferro points to important new research: "In this patient population, the direct comparison between Clopidogrel and the combination of aspirin with extended release Dipyridamole did not reveal any difference between both strategies." Both approaches have proven to be slightly more effective than aspirin alone.
There is also increasing knowledge about higher frequency of compulsive behavior in patients with PD compared to the general population. "These impulse control disorders such as pathological gambling, hyper-sexuality, compulsive shopping, compulsive eating or compulsive overuse of dopaminergic drugs can lead to monetary losses or worsen social handicap of PD patients," Professor Bassetti explains.
ArcelorMittal and the American Red Cross are launching a new national partnership, Creating Safer Communities, designed to bring important safety training and res to people who live and work in communities where ArcelorMittal operates. ArcelorMittal, the world"s leading steel company, provided a grant of $152,500 to be distributed in multiple communities across the US. The program will provide health and safety education to more than 1,800 community members in addition to thousands of ArcelorMittal employees and their families.
Venezuela To Void Some Pharmaceutical Patents
Diabetes UK would like to say a huge "thank you" to everyone who helped to make this year"s Diabetes Week such a great success - we could not have done it without you.
An immediate overhaul of the Department of Veterans Affairs disability claims processing system is the only way out of a fast-growing nationwide backlog of unresolved cases, American Legion National Commander David K. Rehbein said after a congressional hearing last Thursday evening.
A new drug-free treatment for asthma has been shown to be effective in an international study of patients with severe, uncontrolled asthma. The results showed statistically significant improvements in quality of life and reductions in asthma attacks and emergency room visits for patients who underwent the treatment.
A study published in the July issue of Anesthesiology offers perhaps the first estimation of how genomic copy number variation (CNV) can influence anesthetic sensitivity and the magnitude of this influence.
Today, President Obama took historic action to save lives, reduce health care costs, and help reduce suffering from heart and lung diseases, cancer, and other tobacco-related illnesses. These illnesses kill hundreds of thousands of Americans every year, and the new law gives us the tools to effectively address this major public health issue. This is a key step forward and an important part of health reform.
Select Rite Aid stores nationwide will host Diabetes Solutions Days on June 23 and 25 offering patients living with diabetes valuable health screenings and self-management solutions. Caregivers and patients alike can benefit from this free chance to get professional advice on the symptoms and treatments for diabetes as well as watching hands-on demonstrations.
In a paper in Nature Geoscience, a team from the National Oceanography Centre, Southampton (NOCS), along with colleagues from TÃøbingen (Germany) and Bristol presents a novel continuous reconstruction of sea level fluctuations over the last 520 thousand years. Comparison of this record with data on global climate and carbon dioxide (CO2) levels from Antarctic ice cores suggests that even stabilisation at today"s CO2 levels may commit us to sea-level rise over the next couple of millennia, to a level much higher than long-term projections from the Fourth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC).
ISPE, a global not-for-profit association of 25,000 pharmaceutical science and manufacturing professionals, announced that it is accepting proposals from pharmaceutical professionals for content that can be included in a variety of its educational res.
Soft Network Users Group (SNUG) is holding its 17th annual conference, for users of SCC Soft Computer"s (SCC) clinical laboratory software solutions, May 18-21 at the Sheraton Sand Key Resort in Clearwater, Florida. This year"s conference, SNUG 2009- Cultivating Knowledge- a Shared 30-Year Journey of Innovation and Excellence, will include a celebration of SCC Soft Computer"s 30th anniversary with clients and SCC staff members. The conference provides educational opportunities through technical sessions and product demonstrations. Established to promote the free exchange of ideas and suggestions, relating to the applications of SCC Soft Computer"s laboratory software package, SNUG is also a vehicle of communication between users and SCC.
Children who live in Afghanistan are particularly affected every day by a multitude of war time stressors which increase the likelihood of developing PTSD: trauma, child labor, and family and military violence. On a daily basis they are first-hand witnesses to the bombings, abuse, and the general upheaval of their home life and society as a result of war, including the effects of long-term poverty and familial turmoil.
We humans prefer to be addressed in our right ear and are more likely to perform a task when we receive the request in our right ear rather than our left. In a series of three studies, looking at ear preference in communication between humans, Dr. Luca Tommasi and Daniele Marzoli from the University "Gabriele d"Annunzio" in Chieti, Italy, show that a natural side bias, depending on hemispheric asymmetry in the brain, manifests itself in everyday human behavior. Their findings were just published online in Springer"s journal Naturwissenschaften.
Companies are being reminded of their duty to protect their workforce, especially workers from other countries, after a migrant worker employed at a pet bedding company suffered serious injuries in a shredder.
Scientists at the European Molecular Biology Laboratory (EMBL) and the University Clinic Heidelberg, Germany, have produced a three-dimensional reconstruction of HIV (Human Immunodeficiency Virus), which shows the structure of the immature form of the virus at unprecedented detail. Immature HIV is a precursor of the infectious virus, which can cause AIDS. The study, published in the 22-26 June online edition of PNAS, describes how the protein coat that packages the virus" genetic material assembles in human cells. Drugs that block this assembly process and prevent the virus from maturing into its infectious form are considered a promising therapeutic approach.
According to a recent article in the New Yorker, college students are taking neurological drugs like Adderall and Ritalin to help them party hard -- while giving them an academic edge. What"s even worse is that this trend isn"t just occurring in colleges. Parents are giving their young kids Ritalin to help them gain a competitive advantage over their peers, even when they"re not suffering from ADD or ADHD.
A team of scientists led by chemist and NWO Pioneer laureate Piet Gros and medical microbiologist Jos van Strijp from Utrecht University have succeeded in freezing a chain reaction of the immune system. This achievement marks a breakthrough in the field of immunology. The researchers from Utrecht University, University Medical Centre Utrecht and the University of Pennsylvania, published their findings on 7 June with two simultaneous articles in Nature Immunology.
Melatonin can slow down the effects of aging. A team at laboratoire Arago in Banyuls sur Mer (CNRS / Universitç© Pierre et Marie Curie) has found that a treatment based on melatonin can delay the first signs of aging in a small mammal. These results appeared in the journal PLoS ONE on 15 June 2009.
Medical scientists at the University of Leicester are investigating how a species of fish from the Pacific Ocean could help provide answers to tackling chronic conditions such as hereditary high blood pressure and kidney disease.
Abbott announced that it has received CE Mark (Conformite Europeenne) for its next-generation XIENCE PRIME(TM) Everolimus Eluting Coronary Stent System for the treatment of coronary artery disease. The company plans to launch XIENCE PRIME in a broad size matrix with lengths up to 38 mm in Europe in the third quarter.
Accu-Chek has launched an award-wining website for people with diabetes. Patients can now be informed about Accu-Chek"s news and products via an award-winning site packed with engaging interactive tools, such as videos and an online ordering facility, in a layout which allows the user to surf effortlessly through the content.
An elderly Baltimore metro area resident with serious underlying medical conditions and a novel H1N1 influenza virus infection has died, according to the Department of Health and Mental Hygiene (DHMH). Among other complications, H1N1 flu was a contributing factor, making this Maryland"s first death confirmed to be associated with the novel flu strain. Personal details about the case, including specific underlying health conditions, will not be released to protect the privacy of the resident and the resident"s family.
New research from scientists in the US and Greece suggests that the health and longevity effects of the Mediterranean Diet are more strongly
"Some governors are pushing to scale back or kill proposals to expand Medicaid to provide health-care coverage to the uninsured, raising a new challenge to President Barack Obama"s effort to overhaul the system," The Wall Street Journal reports. Health care proposals in the House and Senate "would expand the program to cover at least a third of the nation"s 46 million uninsured, but states are worried they would get stuck with a big part of the tab." Medicaid is "expected to be a primary topic" when a group of governors -- "including Democratic Gov. Christine Gregoire of Washington and Republican Gov. Haley Barbour of Mississippi" -- head to Washington, D.C., this week "to discuss health care with White House and congressional officials."
President Obama is causing the "core culture-war battle" over sex education to "come full circle" by proposing to redirect funding for abstinence-only sex education to a new Teen Pregnancy Prevention Initiative that "rejects an abstinence-only approach," Washington Times columnist Cheryl Wetzstein writes. According to Wetzstein, Obama"s fiscal year 2010 budget plan "zeroed out" the Title V abstinence-only sex education grant program, set to expire on June 30, and the Community-Based Abstinence Education program. Wetzstein continues that groups supporting comprehensive sex education have "loathed Title V from its inception" because of its "prohibition on teaching teens how to use birth-control products (i.e., no condom demonstrations) and its eight-point definition that seemed utterly unrealistic to sex educators." For example, Title V"s definition said that the ""expected standard of human sexual activity"" was a ""mutually faithful, monogamous relationship in the context of marriage,"" which Wetzstein says she has "heard many times, was insulting to gay youth who couldn"t marry" and "insensitive to minority youth who grew up in neighborhoods where marriage was rare." Wetzstein asks, "What will happen to Title V?" She writes that opponents "are staying vigilant" and working to avoid "any last-minute, back-door revivals of this program." Groups that support abstinence-only sex education are "working the phones, too," Wetzstein reports. According to Wetzstein, Valerie Huber, executive director of the National Abstinence Education Association, noted that "[s]aving Title V will require some heavy lifting, but "it"s expired before and been retroactively renewed."" Wetzstein concludes that "we"ll soon see what happens with the new players in town" (Wetzstein, Washington Times, 6/23).
Dutch biopharmaceutical company Crucell N.V. (Euronext, Nasdaq: CRXL) (SWISS: CRX) today announced the results of a second phase II clinical study of its investigational rabies monoclonal antibody combination, which started in May 2008 in the Philippines.
MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX) today announced that the Company has submitted an application for the authorization of a phase 1b/2a clinical study in patients with active rheumatoid arthritis (RA) for its lead drug MOR103, a fully human HuCAL-derived monoclonal antibody directed against Granulocyte Macrophage-Colony Stimulating Factor. The trial, which will be conducted in multiple centers in several European countries, is expected to enroll 135 patients in total beginning in the second half of 2009. Additionally, the Company today reported positive results from the phase 1 clinical study for MOR103 in healthy volunteers. The results of this study indicate that MOR103 is generally safe and well tolerated at all doses administered.
Allosteric modulation company Addex Pharmaceuticals (SWISS: ADXN) announced today that its partner Ortho-McNeil- Janssen Pharmaceuticals Inc. (OMP) has started Phase I testing of ADX71149, a metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulator (PAM). This product, which has potential to treat schizophrenia, anxiety, depression and other CNS disorders, is the first PAM of any mGluR subtype to enter clinical trials. Targeting mGluR2 with a PAM is a novel approach that may offer advantages over classical drug approaches. In reaching this milestone, Addex received a EUR 1 million payment from OMP and remains eligible for additional development milestones and royalties.
Multiple sclerosis, diabetic neuropathy, and other conditions caused by a loss of myelin insulation around nerves can be debilitating and even deadly, but adequate treatments do not yet exist. That"s in large part because of deficiencies in model research systems. In an upcoming issue of the journal Biomaterials, a UCF team addresses this problem with a report on the first lab-grown motor nerves that are insulated and organized the same way they are in the body. The group"s model system, along with further advances now within reach, could dramatically improve understanding of the causes of myelin-related conditions, and enable discovery and testing of new drug therapies.
Dr. Janet D. Latner, an Associate Professor of Psychology at the University of Hawai"i at Manoa, has co-authored an article in the July 2009 edition of the Journal of Sex & Marital Therapy on "Weight Stigma in Existing Relationships."
The National Institutes of Health (NIH) has awarded scientists at Washington University School of Medicine in St. Louis four grants totaling $19 million to explore the trillions of microbes that inhabit the human body and determine how they contribute to good health and disease.
Kamalesh Sirkar, PhD, distinguished professor of chemical engineering at NJIT, and internationally-renowned expert in membrane separation technologies will be the recipient of the NJIT Board of Overseers Excellence in Research Prize and Medal. The award presentation and lecture will take place Wednesday, Oct. 7, 2009, in Kupfrian Hall on the NJIT campus.
CEL-SCI CORPORATION (NYSE AMEX: CVM) announced that it has filed a provisional U.S. patent application covering its L.E.A.P.S.(TM) immune therapy drugs (vaccines) for the prevention/treatment of H1N1, swine, bird flu, Influenza A and/or evolving mutants or variants of these viruses. Some experts believe that by the next flu season the swine flu virus will have evolved and/or combined with other viruses to create a much more lethal new virus. That is what happened in the case of the Spanish flu pandemic. CEL-SCI"s efforts to fight this virus are focused on using conserved epitopes from essential proteins to be found in the A influenza virus for H1N1, H1N5, swine, bird flu and Spanish influenza to create an effective vaccine/treatment that could potentially fight such a mutant virus.
From the west to east coast, Americans are experiencing record-breaking temperatures. Some states are reporting triple-digit numbers and the heat has been the cause of several reported deaths. "Children and the elderly are considered the most vulnerable population. It is harder for their bodies to respond to these high temperatures," said Richard N. Bradley, M.D., associate professor of emergency medicine and chief of EMS and disaster medicine at The University of Texas Medical School at Houston.
Quercetin may not be a household word -- yet.
In his address at the University of Notre Dame"s commencement ceremony on Sunday, President Obama urged advocates on both sides of the abortion-rights debate to treat each other with civility and find ways to work together on common goals, such as reducing the number of unintended pregnancies, the New York Times reports. Obama, who also received an honorary degree from the Roman Catholic university, called for more "open hearts, open minds, fair-minded words" on an issue that has long polarized the U.S. Obama said that although not all will agree on abortion rights, people "can still agree that this heart-wrenching decision for any woman is not made casually" and "has both moral and spiritual dimension." He continued, "So let us work together to reduce the number of women seeking abortions," by reducing unintended pregnancies, making "adoption more available," and providing "care and support" to women who carry pregnancies to term. Obama also said he supports a "sensible conscience clause" that would allow health care workers to withhold services they find morally or religiously objectionable, the New York Times reports. The president said that "[e]ach side will continue to make its case to the public with passion and conviction. But surely we can do so without reducing those with differing views to caricature" (Baker/Saulny, New York Times, 5/18).According to the Wall Street Journal, Notre Dame"s invitation to Obama "amplified longstanding tensions" between the Catholic Church"s position against abortion rights and Catholic universities" academic freedom. Several Catholic bishops and antiabortion-rights advocates argued that it was wrong to honor Obama because of his support for abortion rights, while the university"s leadership and others said it is necessary to communicate with people of opposing views (Meckler, Wall Street Journal, 5/18). Notre Dame"s president, the Rev. John Jenkins, in his introduction of Obama praised the president for agreeing to speak at the ceremony. He said that although some individuals "might have avoided this venue" because of the abortion issue, Obama "is not someone who stops talking to those who differ with him" (Evans, USA Today, 5/18). Jenkins also said, "If we want to extend courtesy, respect and love and enter into dialogue, then surely we can start by acknowledging what is honorable in others" (Dinan, Washington Times, 5/18).The New York Times reports that about 100 abortion-rights opponents protested on the edge of Notre Dame"s campus, and nearly 40 protesters were arrested trying to enter the campus (New York Times, 5/18). According to the Washington Post, more than 70 Catholic bishops criticized the university"s invitation, and more than 360,000 people signed a petition calling for the university to rescind the invite. The Post also reports that 26 of the 2,900 graduates chose to skip the commencement ceremony in protest of Obama"s speech (Shear, Washington Post, 5/18). However, the bulk of the audience at the ceremony "enthusiastically supported" the president, the New York Times reports. A few graduates pasted crosses and replicas of infants" feet on their mortarboards in protest of Obama"s visit, while some supporters displayed Obama"s campaign logo. Four protesters interrupted the speech with shouting and were removed by security guards; audience members responded to the shouting with Notre Dame chants and shouts of "Yes, we can," an Obama campaign slogan. The New York Times reports that while Obama has tried to avoid confrontation on the issue of abortion rights, the controversy over this Notre Dame speech and his pending nomination to replace retiring Supreme Court Justice David Souter have "pushed the issue to the forefront" (New York Times 5/18). Obama"s speech comes as his administration initiates its first meetings between advocates on both sides of the debate to discuss ways to reduce unintended pregnancies and the need for abortion. The meetings, which began at the beginning of May, are expected to continue for the next few
Compugen Ltd. (NASDAQ:CGEN) announced that CGEN-25007, a novel peptide antagonist of gp96 with potent anti-inflammatory activity, has shown positive therapeutic effects in an animal model of inflammatory bowel disease (IBD), a commonly used term covering ulcerative colitis and Crohn"s disease.
Robert Wood Johnson University Hospital and UMDNJ-Robert Wood Johnson Medical School jointly announce the successful implant of the AbioCor® Total Replacement Heart, the world"s first completely self-contained, fully implantable artificial heart, as well as the first internal artificial organ. The surgery was led by Mark Anderson, MD, associate professor of surgery at UMDNJ-Robert Wood Johnson Medical School and chief of the section of cardiac surgery at both the medical school and Robert Wood Johnson University Hospital, and assisted by Juan Plate, MD, assistant professor of surgery at UMDNJ-Robert Wood Johnson Medical School and an attending surgeon at Robert Wood Johnson University Hospital. Robert Wood Johnson University Hospital is one of only three centers nationwide approved to perform the surgery and the only one in the New York and Philadelphia areas. Dr. Anderson is one of a handful of physicians nationwide trained to perform this procedure. This is the first time the AbioCor has been implanted in a patient since the completion of clinical trials and approval by the Food and Drug Administration.
"As President Obama"s effort to overhaul the health care system seems to hit one roadblock after another in Congress, he is counting on Senator Max Baucus [D-Mont.], a political shape-shifter and crafty deal maker who is not fully trusted by either party, to help him clinch his top domestic priority," the New York Times reports in a profile of the Senate Finance Committee leader. Sen. Chris Dodd, D-Conn., has been unable to garner GOP support. Obama"s preferred health leader, Tom Daschle, dropped out of the Obama team because of tax problems and highly partisan House Democrats have failed to work with Republicans, leaving the task of ushering a bill through the legislative process largely to Baucus.
The Washington Post"s Ezra Klein spoke with surgeon and writer Atul Gawande. Klein writes: "Gawande"s New Yorker article comparing the medical systems of El Paso and McAllen, Tex., has been a definitional piece in the health reform conversation. President [Barack] Obama has repeatedly invoked it. Senators have talked about it. The media have embraced it. I spoke to Gawande this afternoon about the fallout from his article, the problem of revenue-driven medicine, and whether a public plan would make a difference."
Medicaid providers in California won a legal challenge over program cuts in the case "Maxwell-Jolly v. Independent Living Center of Southern California." McKnight"s Long Term Care News reports that "The U.S. Supreme Court has let stand a federal appeals court ruling that says California"s Medicaid providers have a right to challenge state cuts to Medi-Cal provider fees. Victor Norma Jean Vescovo, the executive director of the Independent Living Center of Southern California, says the ruling will make it easier to ensure state Medicaid (known in the state as Medi-Cal) cuts will be made for needs-based reasons, not just economic reasons, the Bureau of National Affairs reported.
The journal Lancet Infectious Diseases examines whether President Obama is fulfilling his campaign promises to tackle HIV/AIDS abroad and at home. Although Obama has surrounded himself "[w]ith lauded experts ò€¦ concerns have been raised by activists that investment plans are not matching up to the rhetoric," Lancet writes.
The Rheumatology Futures Project and the Department of Health have launched a new 18-week commissioning pathway for inflammatory arthritis (IA).
The National Association of Chain Drug Stores (NACDS) today announced that the 2009 NACDS Pharmacy & Technology Conference will provide a forum at which to provide further recognition to Leonard J. DeMino, RPh., a chain pharmacy icon whose resume already includes some of the industry"s highest honors and achievements. This news comes as DeMino announces his retirement as senior pharmacy consultant to NACDS, effective in June 2009.
Tobacco acts as a precipitating factor for headaches, specifically migraines. This is indicated in a study which shows that smokers have more migraine attacks and that smoking more than five cigarettes a day triggers this headache. The work has appeared in the Journal of Headache and Pain.
Apthera, Inc. announced that it reached an agreement with the U.S. Food and Drug Administration (FDA) under a Special Protocol Assessment (SPA) for its planned Phase III clinical trial of the Company"s lead drug, NeuVax. The SPA is a written agreement between the trial"s sponsor and the FDA regarding the design, endpoints, and planned statistical analysis of the Phase III trial to be used in support of a Biologics License Application (BLA).
Dr. Arne Ostman and colleagues at the Karolinska Institutet in Stockholm have identified a stromal marker for breast cancer progression. They present these findings in the July 2009 issue of the American Journal of Pathology.
Two NYU Langone Medical Center researchers have received $1,560,000 in grant support for their first year of studies focused on microbiome and psoriasis and on microbiome and esophageal cancer from the National Institutes of Health (NIH). The studies being conducted at NYU Langone Medical Center are two of several projects being conducted through the NIH Roadmap for Medical Research as part of the Human Microbiome Project (HMP) taking place at institutions across the country.
At the 8th International Conference on Bipolar Disorder this week in Pittsburgh, four distinguished individuals will be honored for their contributions to bipolar disorder research, education and service. The conference is the only venue in the world devoted exclusively to highlighting new research into bipolar disorder
Finalising a review of the safety and efficacy of
High serum ferritin, being a hallmark of hereditary hemochromatosis , is frequently found in chronic hepatitis C, alcoholic or non-alcoholic steatohepatitis and non-alcoholic fatty liver disease patients . A study in Italy has investigated the link between ferritin and steatosis in a non-obese cohort of non-alcoholic patients. In southern European populations, high ferritin levels, after exclusion of diagnosis of HH, represent a risk factor for steatosis and clinical relevance, being associated with low platelet count.
The National Center for Catastrophic Sports Injury Research based at the University of North Carolina at Chapel Hill has released its 26th annual all sports report.
If a lump is found in the breast of an adolescent girl, she often will undergo an excisional biopsy.