Public Health
The criteria used to assess blood alcohol concentrations (BACs) and binge drinking behaviors in children and adolescents should be based on pediatric rather than adult physiology, according to a new University of Pittsburgh study in the June issue of Pediatrics.
Bayer HealthCare LLC., Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX), OSI Pharmaceuticals, Inc. (Nasdaq: OSIP) and Roche today announced the initiation of a Phase 3 trial examining Nexavar(R) (sorafenib) tablets in combination with Tarceva(R) (erlotinib) tablets as a potential new treatment option for patients with advanced hepatocellular carcinoma (HCC), or primary liver cancer.
In a sign of the challenges facing seniors on Medicare, a new study finds that older Americans are more likely to make poor choices when faced with a wide array of drug-coverage plans. Making matters worse, many are confident they made the right decisions.
Scientists in Portugal and France managed to follow the patterns of gene expression in food-poisoning bacteria Listeria monocytogenes (L. monocytogenes) live during infection for the first time. The work about to be published in PLoS Pathogens shows how the bacterial genome shifts to better adapt to infection by activating genes involved in virulence and subversion of the host defences, as well as adaptation to the host conditions. This is the first time that the molecular interactions between L. monocytogenes and its host, as they occur during the different steps of infection, are followed in real time paving the way, not only to the development of new therapies against this potentially lethal bacterium, but also for the study of other pathogen/host interactions.
QIAGEN (NASDAQ: QGEN; Frankfurt Prime Standard: QIA) announced that it has entered into an agreement to supply molecular sample and assay technologies for a new national, PCR-based blood screening program for HIV and Hepatitis C (HCV) in Brazil. QIAGEN will provide Bio-Manguinhos, the main provider of vaccines and diagnostics to the Brazilian Ministry of Health, with a significant volume of molecular testing solutions - sample and assay technologies, related instrumentation, operational know-how and training. Following the approval by the Brazilian patent authorities, the agreement will run for five years and contains options for subsequent extensions.
Several newspapers recently published editorials on President Obama"s nomination of Judge Sonia Sotomayor to the Supreme Court. Summaries appear below.~ Boston Globe: "Some liberal activists hoped that Obama would seek a firebrand to counter [Supreme Court Justice] Antonin Scalia, the darling of the right," but "Sotomayor has made her reputation not on hot-button social issues but on matters ranging from environmental regulation to the baseball business," a Globe editorial states. It adds that while Sotomayor "presumably shares Obama"s support for abortion rights, she upheld the Bush administration"s restrictions on family-planning activities" by international groups that received U.S. funding. Now, "conservative groups have seized upon an offhand remark in 2005" when she described the "federal appeals courts as the place "where policy is made" ... as evidence that Sotomayor would legislate from the bench," the editorial states, adding. "The attack is disingenuous." The editorial concludes, "Short of any unexpected revelations about her record or her philosophy, though, the Senate should confirm Sonia Sotomayor," adding that in addition to her "intriguing" personal background she "also has the experience to make an excellent Supreme Court Justice" (Boston Globe, 5/27).~ Chicago Tribune: Sotomayor "has to bring more than diversity to the court," a Tribune editorial states, adding that the "evidence so far suggests that she is up to the job." One "would expect a nominee chosen by Obama to be on the liberal side of the judicial spectrum," but some of her rulings "suggest otherwise," according to the editorial. While Sotomayor "has stressed that the "duty of a judge is to follow the law, not to question its plain terms,"" on the bench, "she ruled against an abortion-rights group challenging" the Bush administration"s "global gag rule," the editorial notes, among other rulings that "could be characterized as "conservative decisions"." However, "the point is not that she"s a closet conservative -- it"s that ideology didn"t seem to determine her decisions," according to the editorial. The "Senate has a responsibility to undertake a thorough examination of her record and her thinking," the editorial states, concluding, "But for now, it looks as though her critics have a tough task ahead of them" (Chicago Tribune, 5/27).~ Los Angeles Times: "Sotomayor doesn"t possess the political experience that would be brought to the court"s cloistered chambers by Michigan Gov. Jennifer Granholm (D) or Homeland Security Secretary Janet Napolitano," but "she satisfies Obama"s other criteria: experience, erudition and, as he put it, "a common touch and a sense of compassion, an understanding of how the world works and how ordinary people live,"" a Times editorial states. Sotomayor"s "experiences as a Latina raised in a housing project who went on to excel at Princeton and Yale don"t in themselves qualify her for the court," but these facts do "complement her sterling credentials and equip her with perspectives that could illuminate legal issues that come before her," the editorial continues. Senate Republicans "should accord her the same respect [they] demanded for Bush"s nominees and end the tiresome tit-for-tat that has cheapened the confirmation of federal judges and deprived the bench of some of the nation"s most capable legal minds," the editorial concludes (Los Angeles Times, 5/27).~ Philadelphia Inquirer: "Sotomayor would bring to the court a diversity it has lacked for most of its history," an Inquirer editorial states. Although "[c]onservatives want to make an issue out of President Obama"s search for "empathy" in a nominee" and "criticize Sotomayor for a speech in 2001 in which she said that being a woman of color affects her decisions," neither comment "is sinister nor shocking," according to the editorial. It concludes, "The Senate has a duty to examine Sotomayor"s qualifications rigorously and fairly. But she appears to have the experience and the
Since the implementation of the Massachusetts health insurance law in 2006, more residents have health coverage and increased access to care, but rising health care costs combined with the current economic recession could undermine some of the law"s successes, according to the third annual "Update on Health Reform in Massachusetts" report by the Urban Institute, the Boston Globe reports. The study was funded by the Blue Cross and Blue Shield of Massachusetts Foundation, the Robert Wood Johnson Foundation and the Commonwealth Fund, and published in the journal Health Affairs.For the report, Sharon Long of the Urban Institute and colleagues surveyed about 4,000 Massachusetts adults in 2007 and 2008 and compared their health care habits with those of residents surveyed in 2006 -- just after the law went into effect. Researchers found that although there were initial gains in health care affordability, there are now some signs that an increasing number of state residents are reporting problems paying for medical bills, and an increasing number of people -- especially lower-income residents -- not seeking care because of costs (Lazar, Boston Globe, 5/28). One in five adults reported being told in the past 12 months that a physician or clinic was not accepting new patients or would not see patients with their type of insurance (Sack, New York Times, 5/28). Lower-income residents had more difficulties finding a physician than higher-income residents, with 24% of residents enrolled in state-subsidized health plans, saying they were told that a physician did not accept their insurance, compared with 7% of residents with private coverage (Boston Globe, 5/28). Additional Findings
A recently released survey on stigma in Rwanda indicates that at least 74% of people in various segments of society who have experienced discrimination are HIV-positive, the New Times/AllAfrica.com reports. The discrimination often is in the form of isolation from family and physical harassment, according to the survey. The study was conducted by the Association of Vulnerable Widows Infected and Affected by HIV and AIDS in conjunction with the Network of People Living with HIV and UNAIDS Rwanda. It found that although 87% of respondents reported never having been denied health services, 88% reported being denied other social services, such as family planning, because of their HIV status. An estimated one-third of respondents reported that their rights had been abused because of their HIV-positive status. Chantal Nyiramanyana, AVVAIS president, said, "We conducted this survey as a way of providing basis for advocacy, policy change, and programmatic interventions by the government and other interested bodies to address stigma and discrimination related to HIV." The survey found that other groups experiencing stigma in the country include commercial sex workers and asylum seekers (Kwizera, New Times/AllAfrica.com, 5/27).
Interson announces the launch of the SeeMore USB Ultrasound Imaging probe. Inexpensive and portable, SeeMore probes plug directly into the USB port of a laptop, netbook, or desktop computer. General purpose and specialty probes are available for a wide range of clinical applications including: abdominal, OB/GYN, bladder scanning, emergency, vascular access, small parts, musculo-skeletal, nerve blocks, endocavity (prostate, transvaginal) and more, and range in frequency from 3.5 MHz to 24 MHz.
International Stem Cell Corporation (OTCBB:ISCO), the first company to perfect a method of creating human "parthenogenetic" stem cells from unfertilized eggs, has received positive early results from animal trials designed to improve photorefractive keratectomy (PRK), a form of corrective laser eye surgery that offers an improved alternative to LASIK.
Genome Institute of Singapore scientists, led by Christopher Wong, Ph.D., have developed a novel approach to uncover the complete sequence of any influenza A virus, including H1NI, with just a quick nasal swab or nasal pharyngeal wash from patients.
VIB researchers linked to K.U.Leuven and Harvard University show that stretches of DNA previously believed to be useless "junk" DNA play a vital role in the evolution of our genome. They found that unstable pieces of junk DNA help tuning gene activity and enable organisms to quickly adapt to changes in their environments. The results will be published in the reputed scientific ournal Science.
Mice carrying a "humanized version" of a gene believed to influence speech and language may not actually talk, but they nonetheless do have a lot to say about our evolutionary past, according to a report in the May 29th issue of the journal Cell, a Cell Press publication.
Two studies in the May 29th issue of Cell, a Cell Press publication, have taken advantage of new technological advances to search for and find previously unknown weaknesses in a hard to treat form of cancer. The discoveries lend new hope in the fight again tumors that are today considered "undruggable."
The Board of Somerset Primary Care Trust will be holding its next Board meeting at 10.00 am on Wednesday 3rd June 2009 at Wynford House, Lufton Way, Lufton, Yeovil. Somerset. BA22 8HR.
Boehringer Ingelheim announced today that it will become the founding sponsor of the World Stroke Academy, a novel training initiative for stroke professionals being developed by the World Stroke Organization (WSO). This latest educational initiative from the WSO will bring together an international group of stroke experts - led by Professor Michael Brainin of the Danube University Krems, Austria - to provide information about stroke and knowledge for health professionals and medical doctors in order to improve prevention, therapy and management of stroke.
When someone becomes dependent on drugs or alcohol, the brain"s pleasure center gets hijacked, disrupting the normal functioning of its reward circuitry.
Oxidative stress has been linked to aging, cancer and other diseases in
In response to industry demand, VIBevents is proud to announce the launch of the industry"s first virtual clinical trials event, ClinicalTrialsArena.com, which will bring together the leading decision makers within the pharma and biotech industries.
Boehringer Ingelheim announced that it will become the founding sponsor of the World Stroke Academy, a novel training initiative for stroke professionals being developed by the World Stroke Organization ( WSO). This latest educational initiative from the WSO will bring together an international group of stroke experts - led by Professor Michael Brainin of the Danube University Krems, Austria - to provide information about stroke and knowledge for health professionals and medical doctors in order to improve prevention, therapy and management of stroke.
BMA Scotland has published a series of briefing papers providing evidence to support further legislation to crack down on tobacco promotions and ban cigarette vending machines in Scotland. The BMA is calling on MSPs to support the proposals contained in the Tobacco and Primary Medical services (Scotland) Bill and urging them not to be swayed by the "scaremongering" tactics of the tobacco industry and retailers.
Small Bone Innovations, Inc. (SBi), a leading provider of innovation, products, technology and education for the small bone & joint segment of the orthopedics industry, announced that the U.S. Food and Drug Administration (FDA) has approved SBi"s Scandinavian Total Ankle Replacement (S.T.A.R.®) system to treat U.S. patients. S.T.A.R. has received pre-market approval (PMA) to replace a painful arthritic ankle joint due to osteoarthritis, post-traumatic arthritis or rheumatoid arthritis.
Although a large number of children"s hospitals have developed or are developing policies regarding organ donation after cardiac death, there is considerable variation among policies, including the criteria for declaring death, according to a study in the May 13 issue of JAMA.
Midwifery Regulators from eighteen European countries have met in London to discuss ways in which they can collaborate to enhance the safety of women and babies across the EU.
Sleep disturbances increase as we age. Some studies report more than half of seniors 65 years of age or older suffer from chronic sleep disturbances. Researchers have long believed that the sleep disturbances common among the elderly often result from a disruption of the body"s circadian rhythms - biological cycles that repeat approximately every 24 hours.
APS Healthcare, a leading provider of specialty healthcare solutions, has been selected by the Oregon Department of Human Services (DHS), Division of Medical Assistance Programs, to manage its statewide Medicaid disease and medical care management programs. The integrated program will assist Oregon"s Medicaid and SCHIP fee-for-service clients to access healthcare, minimize catastrophic health events and improve health outcomes through education and interventions that help promote behavior change.
Researchers at the University of Southern California (USC) and USC Norris Comprehensive Cancer Center will present breakthrough research in a number of researchstudy areas at the 2009 American Society of Clinical Oncology (ASCO) annual meeting in Orlando, Florida.
Two of the world"s leading Alzheimer"s researchers have co-edited a book critically synthesizing the major new developments in the diagnosis and treatment of Alzheimer"s disease. Building upon a 2007 Alzheimer"s disease conference held in Chile, George Perry, dean of the College of Sciences at The University of Texas at San Antonio (UTSA) and Ricardo B. Maccioni, neurology professor at The University of Chile Medical School have edited "Current Hypotheses and Research Milestones in Alzheimer"s Disease," a 254-page text written by academics and medical doctors. The book focuses on the most promising hypotheses that illuminate the path to more effective treatment.
The University of California, San Francisco (UCSF) and the Multiple Myeloma Research Foundation (MMRF) have established the Stephen and Nancy Grand Multiple Myeloma Translational Initiative, a research collaboration dedicated to translating basic science discoveries into new candidate drugs for testing in clinical trials.
Although heart failure is a chronic condition, acute exacerbations are frequent and occur with serious complications; patients with heart failure and their families can help improve prognosis in acute events if they are taught to recognise the tell-tale signs of worsening condition and seek immediate medical help. "Any delayed recognition of these signs is associated with an increased rate of hospitalisation and complications, including mortality," says Professor Ferenc Follath from the University Hospital of Zurich, Switzerland.
The individualised management programme of France"s "Réseau Respecti-coeur" makes quality of life the first objective for heart failure patients, and one of the network"s dieticians, Mme Hélène Guibert, explained that the heart-healthy eating recommended in the programme need not be a of frustration or misery - even for a Frenchman. "For many old people," she told Heart Failure Congress 2009, "meals are important occasions, and it"s our aim to bring together at these times health and pleasure."1,2
People who feel pressure to look attractive are more fearful of being rejected because of their appearance than are their peers, according to a new study by researchers at the University at Buffalo and the University of Kent.
Drug-facilitated sexual crimes are increasing. The Bonn Institute for Forensic Medicine has recorded that the number of examinations on the use of intoxicants in sexual offences within their catchment area increased 10-fold between 1997 and 2006. In the current edition of Deutsches Arzteblatt International, Burkhard Madea and Frank Musshoff present the modes of action and the detection windows for the most frequent substances (Dtsch Arztebl Int 2009; 106 (20): 341-347).
As the childhood obesity epidemic in the United States continues, researchers are examining whether early parent and child behaviors contribute to the problem. A study from the Department of Nutritional Sciences, Rutgers University, published in the May/June 2009 issue of the Journal of Nutrition Education and Behavior reports that mothers who miss signs of satiety in their infants tend to overfeed them, leading to excess weight gains during the 6 month to 1 year period.
A new study is the first to show that there is a previously unrecognized role for environmental pollution in liver disease in the general U.S. adult population. This work builds upon the groups" previous research demonstrating liver disease in highly-exposed chemical workers. The study is being presented during Digestive Disease Week® 2009 (DDW®), the largest international gathering of physicians and researchers in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.
Aetna, Cigna and Humana ranked highest nationally on criteria including speed of health claim payments and fewest claims denied, according to the 2009 PayerView Rankings, the Boston Globe reports. The rankings -- prepared by Athenahealth in collaboration with Physicians Practice management journal -- evaluated 172 national, regional and government payers in 40 states.According to the data, insurers paid physicians an average 5.3% faster in 2008 and denied an average of 9% fewer medical claims compared with 2007 figures. On average, national health insurers paid physicians in 33 days and denied 9.2% of claims.According to the Globe, the rankings reveal some of the obstacles that can result from the complexities and bureaucracy involved in the medical billing process, with each insurer operating in different ways. Jonathan Bush, chair and CEO of Athenahealth, said, "This is the biggest problem we have in health care -- the inability to close supply chains and to practically and tactically connect doctors with payers and patients," adding, "These connections are broken" (Weisman, Boston Globe, 5/28).
"Blog Watch" offers readers a roundup of health policy-related blog posts.Bloggers are tentatively reacting to a report and blog post released by the Congressional Budget Office that summarizes the agency"s approach to estimating the cost of any health overhaul bills. At issue is how CBO will count different stipulations of legislation -- like an individual mandate or a public plan -- and whether their conclusions will result in a heftier price tag. Douglas Elmendorf explained on the Director"s Blog: "In CBO"s view, the key consideration is whether a proposal would be making health insurance an essentially governmental program, tightly controlled by the federal government with little choice available to those who offer and buy health insurance -- or whether the system would provide significant flexibility in terms of the types, prices, and number of private-sector sellers of insurance available to people. The former -- a governmental program -- belongs in the federal budget (including all premiums paid by individuals and firms to private insurers), but the latter -- a largely private-sector system -- does not." Janet Adamy of the Wall Street Journal"s Washington Wire notes that the report doesn"t address the cost estimates of the scenarios. Alan Katz on his Health Care Reform Blog concludes, "the message is clear: the looser government"s hand grips the new health care system the smaller its budgetary impact." Liberal bloggers had a variety of reactions -- some found the report too vague, while others saw it as good news. The New Republic"s Jonathan Cohn says, "you may need a Talmudic scholar to figure out what those implications are." Cohn continues, "Other passages in the briefing are [similarly] vexing and, for what it"s worth, the reactions I"ve gotten from insiders familiar with the report have ranged from sighs of relief to statements not suitable for a family blog." Ezra Klein agrees the report lacks specificity, but says, "Even so, I"m cheered by the simple existence of this ruling. The fact that CBO is explaining its thinking before legislation arrives [is] yet more evidence that CBO appears, insofar as it can, to be trying to help out on health reform. ... That"s an important change from past years." Interesting Elsewhere:
The following highlights efforts that seek to reduce racial and ethnic health disparities.
If you are a clinical research novice or veteran with a study sponsor, research site, or CRO in a corporate, academic or other organization, you will find a comprehensive program that focuses on your current needs and broadens your knowledge. MAGI conferences feature balanced co-presentations from sponsors, sites and CROs, real-life examples, practical tips, and lots of interaction and networking. This year"s conference will feature:
Dentists are seeing a spike in jaw-pain related
Following calls from the information commissioner for the NHS to improve its data security, after breaches involving the loss of thousands of personal medical records, Bill Gilliam, head of the health sector group at international law firm Eversheds comments:
Final results from a phase II study presented at ASCO show that 25% of women with advanced HER2-positive breast cancer experienced significant shrinkage of their tumours, when treated with a first in class combination antibody called trastuzumab-DM1 (T-DM1). T-DM1 potentially represents another option for patients with metastatic disease, for which there is no cure.
Thieme Publishing Group is pleased to announce the launch of Pharmaceutical Substances Version 3.2. Available via Thieme-connect, Pharmaceutical Substances is a comprehensive reference guide to every significant pharmaceutical compound and includes all FDA approved active pharmaceutical ingredients (APIs).
The lead article in a special supplement on clinical handover in the Medical Journal of Australia relates a tragic case in which an elderly man died for want of effective handover.
A survey of trauma patients reported in the Medical Journal of Australia has found that compensation-related factors are significant predictors of health care utilisation.
Agendia, a world leader in molecular cancer diagnostics, announced
XClinical, a European vendor of innovative software products for eClinical trials, is presenting CDISC based tools for an End-To-End clinical process at the 45th DIA Annual Meeting in San Diego, USA.
With consumer genetics becoming more of a reality to the average consumer and direct-to-consumer (DTC) genetics tests becoming more available, thought leaders, experts and DTC companies will convene in Boston on June 9-11 for the first annual Consumer Genetics Conference to move the issues to the forefront and demystify this emerging field. Preeminent leaders from government, healthcare, biotechnology and diagnostic fields, will examine consumer genetics, including its practical realities and complex policy considerations; speakers and companies will present new advances and information on available genetic tests and developments in this field. The conference is open to all who are curious, impacted by, and interested in consumer genetics, including consumers (http://www.consumergeneticsconference.com).
Sipping wine, beer or spirits three to four times per week increases the risk of binge drinking, particularly among young men, according to a new study published in the journal Addiction. Researchers from the Universitç© de Montrç©al and the University of Western Ontario analyzed the drinking habits of Canadians and found that frequent alcohol consumption can lead to binge drinking among all gender and all age groups.
Talecris Biotherapeutics presented results last week from two phase III studies assessing the safety, tolerability and pharmacokinetic comparability of a more concentrated formulation of Prolastin® (Alpha1-Proteinase Inhibitor [Human]) produced via a modification of the current manufacturing process that incorporates technological changes.
Quest Diagnostics Incorporated (NYSE: DGX), the world"s leading cancer diagnostics company, today launched the EGFR Pathway test (KRAS with reflex to NRAS, BRAF), the first laboratory-developed test from a national commercial reference laboratory for comprehensively identifying, in a single reflex test offering, genetic mutations in the KRAS, NRAS and BRAFL genes. The test is designed to aid the identification of the roughly half of all metastatic colorectal cancer (mCRC) patients who, because of certain mutations of the epidermal growth factor receptor (EGFR) pathway, are believed to be unresponsive to anti-EGFR cancer therapies for mCRC. While some commercial laboratory tests for predicting anti-EGFR response analyze certain mutations of the KRAS and BRAF genes, such as codons 12 and 13 of KRAS, the Quest Diagnostics test detects mutations in codons 12, 13 and 61 of both the KRAS and NRAS genes and mutations in exons 11, 12, and 15 of the BRAF gene, in a sequential reflex manner.
New Phase III study results presented for the first time at the ninth annual American Transplant Congress 2009 (ATC) demonstrate that doubling the duration of preventive therapy ("prophylaxis") with Valcyte (oral valganciclovir) significantly reduced the incidence of CMV disease by 56% in high-risk kidney transplant patients within the first year post-transplant.
Researchers studying a difficult-to-treat form of childhood epilepsy called infantile spasms have developed a line of mice that experiences seizures with features closely resembling those occurring in patients with infantile seizures. These genetically engineered mice provide a new opportunity for scientists to test treatments that may benefit children.
ACCESS PHARMACEUTICALS, INC.(OTC Bulletin Board: ACCP), provided an update on the progress in the Company"s clinical development plan for ProLindac, a novel DACH platinum drug that has shown to be active in many solid tumor types in human clinical studies. Access recently announced positive safety and efficacy results from its Phase 2 monotherapy clinical study of ProLindac(TM) in late-stage, heavily pretreated ovarian cancer patients. In this study, 66% of patients who received the highest dose achieved clinically meaningful disease stabilization according to RECIST criteria. No patient in any dose group exhibited any signs of acute neurotoxicity, which is a major adverse side-effect of the approved DACH platinum, Eloxatin, and ProLindac was well tolerated overall. The Company has scaled up manufacturing in order to begin the next phase of clinical development. Access plans to conduct several combination trials in different solid tumor types both as Company-sponsored trials and in conjunction with its two previously announced co-development partners.
Bayer HealthCare Pharmaceuticals, Inc. and Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) announced that the companies have begun enrolling patients in an international Phase 3 trial to evaluate Nexavar(R) (sorafenib) tablets in patients with non-squamous non-small cell lung cancer (NSCLC) who have failed two or three previous treatments.
Provectus Pharmaceuticals, Inc. (OTC Bulletin Board: PVCT), a development-stage oncology and dermatology biopharmaceutical company, has announced interim data from the first 40 subjects in its Phase 2 clinical trial for the treatment of metastatic melanoma. PV-10 treatment was well tolerated and caused selective tumor destruction in the majority of subjects. Additional data on untreated tumors corroborated observations of a possible bystander effect seen during earlier Phase 1 testing. These data were presented today at the American Society of Clinical Oncology 2009 Annual Meeting, Abstract #9060, entitled "Chemoablation of melanoma with intralesional rose bengal (PV-10)," in the General Poster Session.
Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, presented data from a clinical trial investigating its anti-EpCAM human antibody adecatumumab (MT201) in combination with the chemotherapeutic docetaxel in patients with metastatic breast cancer (MBC) at the annual meeting of the American Society of Clinical Oncology (ASCO) held in Orlando, Florida, USA(1).
Computer scientists at the University of East Anglia (UEA) have developed a new way of cloning facial expressions during live conversations to help us better understand what influences our behaviour when we communicate with others.
Maryland intensive care patients will now be connected by voice, video and data lines to specialized physicians and nurses at a tertiary care referral center 130 miles away. A year after announcing six, independent Maryland hospitals, with a $3 million grant from CareFirst BlueCross BlueShield, were joining together to provide state-of-the-art critical care to their patients, the first hospital, Calvert Memorial Hospital in Prince Frederick, Md., is fully online with the sophisticated care system.
Tumors need a healthy supply of blood to grow and spread. Researchers at the Stanford University School of Medicine have identified a molecule that regulates blood vessel growth that is often found at less-than-normal levels in human tumors. Blocking the expression of the molecule, called PHD2, allows human cancer cells to grow more quickly when implanted into mice and increases the number of blood vessels feeding the tumor.
DxS, a personalised medicine company, and Boehringer Ingelheim, a global group of pharmaceutical companies, headquartered in Germany, have entered into an agreement to provide a companion diagnostic test kit for Boehringer Ingelheim"s compound BIBW 2992 (Tovok™) to identify mutations of the EGFR (epidermal growth factor receptor) in patients with non small cell lung cancer. Financial terms of the agreement are not disclosed.
Findings in mice suggest greater hope for targeting brain cancer, but also greater caution in pursuing stem cell treatments for degenerative diseases
If having malodorous armpits (called osmidrosis) and goopy earwax isn"t bad enough, a discovery by Japanese scientists may add a more serious problem for women facing these cosmetic calamities. That"s because they"ve found that a gene responsible for breast cancer causes these physical symptoms. The report describing this finding is featured on the cover of The FASEB Journal"s June 2009 print issue, and should arm physicians with another clue for detecting breast cancer risk.
In-growth and new generation of blood vessels, which must take place if a wound is to heal or a tumor is to grow, have been thought to occur through a branching and further growth of a vessel against a chemical gradient of growth factors. Now a research team at Uppsala University and its University Hospital has shown that mechanical forces are considerably more important than was previously thought. The findings, published today in the journal Nature Medicine, open up a new field for developing treatments.
"Health industry officials delivered a plan to the White House Monday documenting how they"ll attempt to save $2 trillion over a decade through measures like reducing hospitalizations and cutting down on paperwork," the Associated Press reports. "Health insurers, doctors, hospitals, drug-makers and others were under pressure to make good on a pledge they made last month to curb their own costs to help President Barack Obama achieve his health care overhaul goals." Their three big areas of savings: $150 billion to $180 billion would come from more efficient use of health care services, $350 billion to $850 billion from better management of chronic diseases, and $500 billion to $700 billion through administrative improvements such as standardizing claim forms (Werner, 6/1).
"Facing difficult economic times and the uncertainties of national health care reform, some Maryland hospitals are choosing to be swallowed up by larger medical systems, with an unusual string of mergers over the past 16 months and more likely on the way," The Baltimore Sun reports. The consolidations could offer benefits to all those involved. Small hospitals gain "the hope of safe harbor from whatever financial storms are on the horizon, hospital chains "get footholds in new areas, where they can build market share and increase the number of patients they serve," and patients may "gain access to large networks of top-notch doctors, even if the patients live many miles from a major medical institution."
A Red State Booster Shot - The Washington Post
The New York Times reports on a series of deep budget cuts to help California, which is some $24 billion in the red, deal with its" ongoing financial woes.
ZymoGenetics, Inc. (NASDAQ:ZGEN) announced positive final results from a Phase 2 clinical trial in patients receiving 2nd or 3rd line therapy for advanced renal cell carcinoma with the combination of recombinant Interleukin 21 (IL-21) and Nexavar® (sorafenib) tablets. The combination demonstrated considerable clinical benefit, with an overall response rate (as assessed by an independent review) of 21%, a disease control rate of 82%, and progression-free survival (PFS) of 5.7 months in this heavily pretreated population. Results were presented at the American Society of Clinical Oncology meeting.
High-throughput whole-genome analysis is becoming a standard laboratory approach for investigating cellular processes. Next-generation sequencing is replacing microarrays as the technique of choice for genome-scale analysis, because it offers advantages in both sensitivity and scale. The June issue of Cold Spring Harbor Protocols features "Native Chromatin Preparation and Illumina/Solexa Library Construction" from Keji Zhao and colleagues at the National Heart, Lung and Blood Institute. The article describes sample preparation for sequencing of chromatin-immunoprecipitated DNA (ChIP-Seq) to analyze histone modification patterns using native chromatin and the Solexa/Illumina Genome Analyzer. Step-by-step instructions are given for purification of human CD4+ T cells from lymphocytes and chromatin fragmentation using micrococcal nuclease (MNase) digestion, followed by chromatin immunoprecipitation (ChIP) and construction of a library for sequencing. The article is freely available on the website for Cold Spring Harbor Protocols (http://cshprotocols.cshlp.org/cgi/content/full/2009/6/pdb.prot5237).
Argos Therapeutics announced the presentation of new information on its soluble CD83 (sCD83) protein program in a poster session at the 2009 American Transplant Congress, held May 30-June 3 in Boston. The poster presentation, to be made on June 2 at 5:30pm by Argos" collaborating scientists from the University of Western Ontario, demonstrates that combination therapy with sCD83 can prolong kidney allograft survival in an animal model of transplantation, and that sCD83 attenuates pathological changes in kidney allografts, induces generation of T regulatory cells and inhibits dendritic cell maturation, all of which may contribute to immunosuppression and allograft tolerance.
Sepracor Inc. (Nasdaq: SEPR) today announced that it has been notified by the U.S. Food and Drug Administration (FDA) that the New Drug Application (NDA) for STEDESA™ (eslicarbazepine acetate) has been accepted for filing and is now under formal review. As previously announced, the NDA for STEDESA was submitted to the FDA on March 31, 2009 for adjunctive therapy in the treatment of partial-onset seizures in adults with epilepsy. The acceptance of the filing means that the FDA has made a threshold determination that the NDA is sufficiently complete to permit a substantive review.
Plexxikon Inc. today announced preliminary data from a Phase 1 clinical study investigating PLX4032 (R7204). PLX4032 is a novel, oral and highly selective drug that targets the BRAFV600E cancer-causing mutation that occurs in most melanomas and about eight percent of all solid tumors. In patients whose cancer harbors this mutation and who were treated with therapeutic doses of PLX4032, tumor shrinkage and extended progression-free survival have been observed. Currently, two extension studies are being conducted in mutation-positive melanoma and colorectal cancer patients. Following the initial positive findings announced today, larger clinical trials to support a registration program for product approval are targeted to start later in 2009. Plexxikon and Roche are co-developing PLX4032 under their 2006 license and collaboration agreement.
Black religious leaders across the country are urging the passage of a bill (H.R. 1964) that would provide more than $600 million in funding for faith-based prevention, testing and outreach programs, the St. Petersburg Times reports. The bill, named the National Black Clergy for the Elimination of HIV/AIDS Act of 2009, calls for programs targeting specific populations within the black community, including young people, substance users and inmates, among others. The bill, introduced in Congress this spring, has been referred to the House Committee on Energy and Commerce (Zayas, St. Petersburg Times, 6/1).
The Los Angeles Times on Sunday examined how the recession is impacting people living with HIV in California. Brad Hare, medical director of University of California-San Francisco"s Positive Health Program at San Francisco General Hospital, said that people living with HIV who have lost their jobs and private health insurance are turning to public and nonprofit clinics for the first time and are responsible for a 12% increase this year in the clinic"s overall patient visits. He added that many of the patients he sees have gone months without receiving medical care. In addition, at the Los Angeles Gay and Lesbian Center, which also provides HIV treatment, the number of new patients has doubled over the last year, Thomas Soule, a spokesperson for the center, said. The Times also profiled a client of the center (Lin, Los Angeles Times, 5/31).
Democrats and Republicans are looking for support in their own parties as health care reform promises to dominate the legislative agenda for the rest of the year, The Hill reports.
Several of the country"s largest liberal groups said they were prepared to spend $82 million to promote President Obama"s health care reform agenda, the Boston Globe reports. "Joining the effort are two major labor organizations, the AFL-CIO and Change to Win; Health Care for America Now, a coalition of healthcare providers, consumer groups, and activists; MoveOn.org, the massive online activist organization; and other groups that claim a total of 30 million members."
Hyperion Therapeutics, Inc. announced top-line results from a phase I study of HPN-100 in patients with liver cirrhosis. The data were presented as part of the 2009 Digestive Disease Week meeting. The abstract is titled "Pharmacokinetic (PK) and Safety Analyses of a Novel Ammonia-Reducing Agent in Healthy Adults and Patients with Cirrhosis."
Clinical trial results presented at the Digestive Disease Week in Chicago reveal that endoscopic radiofrequency ablation performed in a community practice setting is safe and effective for eradicating a pre-cancerous esophageal condition known as Barrett"s esophagus. The study is entitled, "Radiofrequency Ablation of Barrett Esophagus: Outcomes of 429 Patients from a Multi-center Community Practice Registry" and was presented today by Ronald E. Pruitt, M.D., Nashville, TN, at a scientific session sponsored by the American Society of Gastrointestinal Endoscopy.
The American Society for Radiation Oncology (ASTRO) has recently updated its award-winning patient booklet, Radiation Therapy for Cancer that provides information for people living with cancer and their loved ones who are exploring radiation therapy as a treatment option.
The American Society of Gene Therapy recently honored three researchers as Outstanding New Investigators in the field of gene therapy.
New research from the UC Davis Center for
In the midst of Zimbabwe"s growing humanitarian crisis, U.N. agencies on Monday released a revised statement of appeal for foreign donations totaling $718 million for "food, clean water, AIDS medicines and other aid - up from an estimate of $550 million in November," the AP/Washington Post reports (Shaw, AP/Washington Post, 6/1).
In the run up to National Tackling Drugs Week (8th-12th June), drug and alcohol services in Liverpool have gathered together to host "Know more" an event which will showcase a range of services that offer advice and support to young people and their families.
Renal diseases shall be diagnosed earlier and treated more successfully in the future. Towards this aim, researchers from nine European countries*, coordinated by the Max DelbrÃøck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have been working for the past four-and-a half years to create a three-dimensional virtual "Kidney Atlas". It incorporates the latest research findings on the development and diseases of the kidney. The Kidney Atlas was part of the European Renal Genome Project (EuReGene), which the European Union (EU) funded with more than 10 million euros. At the conclusion of the project, the Kidney Atlas was presented at MDC during a two-day symposium from May 15-16, 2009, which was attended by approximately 100 researchers.
Research from a survey by Tesco Dental Insurance has revealed Brits are finding it increasingly difficulty to find an NHS dentist. The results also show that rising dental costs are putting people off visiting the dentist.
If Judge Sonia Sotomayor is confirmed to replace retiring Supreme Court Justice David Souter, she would be the sixth Roman Catholic currently on the court, the New York Times reports. According to the Times, although Sotomayor was raised Catholic and attended a Catholic high school, she appears to be in line with the majority of U.S. Catholics who identify themselves with the faith but do not regularly go to Mass or become heavily involved in religious life. Several studies have shown that Catholics who rarely or never attend mass are more liberal on political and cultural issues than those who attend more regularly, the Times reports. For example, a Gallup poll released in March found that 52% of Catholics who do not attend church regularly say abortion is morally acceptable, compared with 24% of Catholics that are regular churchgoers. A White House spokesperson said that Sotomayor "currently does not belongs to a particular parish or church, but she attends church with family and friends for important occasions" (Goodstein, New York Times, 5/31).According to the Boston Globe, the number of Catholics on the court has increased sharply over the past two decades, a shift from earlier years when there generally was one "Catholic seat" on the bench. Although Supreme Court experts say that the increase in the number of Catholic justices reflects a fall in anti-Catholicism over the past half-century, they also note that Catholic justices" views have not always aligned with the Church"s teachings and that a judge"s faith is not necessarily an indicator of how he or she will rule on issues like abortion rights or gay marriage. Current Catholic Supreme Court Justices Clarence Thomas, Antonin Scalia, Anthony Kennedy, Samuel Alito and Chief Justice John Roberts all are in favor of either overturning Roe v. Wade or returning the issue of abortion to the states, the Globe reports. However, there have been previous Catholic justices, such as Justice William Brennan, who were avid supporters of abortion rights (Paulson, Boston Globe, 5/30).Cathleen Kaveny, a professor of law and theology at the University of Notre Dame, said, "I don"t think there is any one Catholic stance on the law," adding, "You"ll have judges who are pro-life personally who are going to rule that [Roe] is the law of the land."Sotomayor "Formidable Counterweight" to Catholic Men on Court, Opinion Piece Says "If anyone should be worrying" about Sotomayor as the sixth Catholic on the Supreme Court, "it"s the five who are already there," former Catholics for Free Choice President Frances Kissling writes in a Salon opinion piece. Roberts, Alito, Kennedy, Scalia and Thomas "all seem cut from the same traditional Catholic (and Federalist Society conservative) mold," Kissling writes, noting that all five voted in Gonzales v. Carhart to uphold the Partial-Birth Abortion Ban Act. If confirmed, Sotomayor"s experience with the other justices "is likely to change [her] as well -- and make her an even more formidable counterweight to the male Catholic bloc," according to Kissling. "There is nothing more likely to radicalize a "moderate" Catholic woman of even marginal religiosity than daily exposure to Catholic men who think women need to be protected from making money or making bad and sad abortion choices," Kissling contends (Kissling, Salon, 5/31).
PharmaPendium, Elsevier"s online re for authoritative preclinical, clinical and post-marketing drug information, has significantly expanded its coverage of US Food and Drug Administration (FDA) approval documents with the launch of the FDA Classic Collection. This collection contains all available historical FDA approval documents up to and including those issued in 1991 - all indexed and made searchable for the first time in history. With the addition of the FDA Classic Collection, PharmaPendium has become the only integrated, searchable of all FDA drug approval documents.
Nearly one percent of the population suffers from bleeding disorders, yet many women don"t know they have one because doctors aren"t looking for the condition, according to researchers at Duke University Medical Center.
The British Dental Association (BDA) has given a broad welcome to today"s announcement of the award of a tender for 38 new dentists in Northern Ireland as part of the solution to the problems some patients face accessing care. But the BDA has also warned that this is not the whole solution to the problems facing Health Service dentistry. Also required, says the BDA, are full support for the more than 800 dentists already working in Northern Ireland and a new contract that allows dentists to provide the kind of modern, preventive care they are trained to do.
There are many reasons why health care costs in the US are spiraling out of control: ineffective use of res, unmanaged chronic conditions and infrequent implementations of proven prevention strategies all contribute. While it stands to reason that preventative actions are one solution, no one has yet quantified the value of investing in non-traditional prevention programs.
Registration forms for the prereg trainee pharmacist programme 2009/10 are now available to download on the NPA members" website. The NPA is also providing training on 26 June 2009 for prereg tutors that have enrolled their prereg on to the NPA"s programme.
Informing men that a new vaccine to prevent human papillomavirus (HPV) would also help protect their female partners against developing cervical cancer from the sexually transmitted infection did not increase their interest in getting the vaccine, according to a new Florida State University study.
Dr Peter O"Meara, Associate Professor in Pre-hospital Care at Charles Sturt University in Australia, is the first non-UK paramedic to be appointed to a three year visiting Professor post in the UK in the subject of Pre-Hospital Care.
A recent clinical trial - led by Goshen Center for Cancer Care - has yielded promising results for the future use of a cancer vaccine. One of the first studies to prove vaccines might have a medical benefit against cancer, study results found the new cancer vaccine doubled the response rate for tumor shrinkage as well as delayed the progression of cancer in patients with metastatic melanoma.
Researchers at Washington University School of Medicine in St. Louis have created a line of fruit flies that may someday help shed light on the mechanisms that cause insomnia in humans. The flies, which only get a small fraction of the sleep of normal flies, resemble insomniac humans in several ways.
Based on the top-level analysis of a Phase II study, EyeGate Pharma announces that EGP-437, a corticosteroid solution administered by a non-invasive ocular drug delivery system, improved signs and symptoms in patients with dry eye syndrome (DES).
Diabetes UK launches its national Measure Up Roadshow today to tackle the diabetes epidemic, as it reveals that more than 1.7 million people in the UK could have avoided developing Type 2 diabetes.
Advanced Life Sciences Holdings, Inc. (OTC Bulletin Board: ADLS) announced that the FDA"s Anti-Infective Drugs Advisory Committee voted in the majority that Restanza(TM) (cethromycin) demonstrated safety for the outpatient treatment of adults with mild-to-moderate community acquired pneumonia (CAP) (11 positive, 3 negative, 1 abstaining). However, the committee voted that Restanza did not demonstrate efficacy in the treatment of CAP (3 positive, 11 negative, 1 abstaining).
An electronic diagnostic tool called the SmartPill is swallowed by patients in order to take measurements as it travels through the gastrointestinal tract. A new study by physician-scientists at NewYork-Presbyterian/Weill Cornell Medical Center used the device in patients with mild to moderate ulcerative colitis (UC), determining that they have significantly more acidic pH in their colons, compared with the average person -- a finding that may impact treatment strategy.
Race season is here again, and that means more first-timers on the marathon/triathlon circuit. Officials from some of the biggest marathons and triathlons in the country are reporting record numbers of participants, many of whom are first-time competitors.
The Senate began debate Tuesday on whether to grant the Food and Drug Administration power to regulate tobacco products, Reuters reports. Debate began after an 84-11 procedural vote and could continue into next week. The Democratic-backed bill "would let the FDA oversee the packaging, marketing and manufacturing of cigarettes and other tobacco products, which have been linked to cancer and other illnesses and kill 400,000 Americans each year."
The Food and Drug Administration is taking steps towards greater openness. The Associated Press reports that FDA Commissioner Margaret Hamburg "announced Tuesday she has created a task force to make recommendations on how the agency can release more information in such areas as drug evaluation and enforcement matters. She wants a report in six months." Deputy Commissioner Joshua Sharfstein will head the task force, which will represent all of the FDA"s major divisions as well as its law enforcement branch. It will hold two public meetings with the first on June 24. "The FDA has long operated under strict confidentiality rules," the AP reports, and in opening up information, one sensitive issue will be what to do with unpublished clinical trial data from drug manufacturers. Despite such concerns, "Hamburg said she believes the need for secrecy may have been taken too far, and is harming the FDA"s credibility within the medical community and among consumers" (Alonso-Zaldivar, 6/2).
Why The Health Care Rush? - The Wall Street Journal
The WHO on Tuesday said it was "getting closer" to declaring the H1N1 (swine) flu outbreak to be a pandemic, as the virus continues to spread to people outside of North America, and in populations "as far apart as Britain, Spain, Japan, Chile and Australia," the AP/Washington Post reports (Jordans, AP/Washington Post, 6/2).
Magellan Spine Technologies, Inc. announced the first human implant of its DART (Disc Annular Repair Technology) System for use after lumbar discectomy procedures. This initial clinical use follows European CE Mark clearance of the DART System in April 2009.
A study by neuroscientist Heather Rupp and her team found that a woman"s partner status influenced her interest in the opposite sex. In the studyÂð, published in the March issue of Human Nature, women both with and without sexual partners showed little difference in their subjective ratings of photos of men when considering such measures as masculinity and attractiveness. However, the women who did not have sexual partners spent more time evaluating photos of men, demonstrating a greater interest in the photos. No such difference was found between men who had sexual partners and those who did not.
Sleeping tablets have been associated with a four-fold increase in suicide risk in the elderly. Researchers writing in the open access journal BMC Geriatrics have shown that, even after adjusting for the presence of psychiatric conditions, sedatives and hypnotics were both associated with an increased risk of suicide.
A promising antimicrobial agent already known to kill bacteria can also kill viruses and stimulate the innate immune system, according to researchers at National Jewish Health. In a paper appearing online June 4 in the Journal of Investigative Dermatology, Michael Howell, PhD, Assistant Professor of Pediatrics, and his colleagues demonstrated that the synthetic compound CSA-13 can kill vaccinia virus in cell cultures and in mice. Additionally, they showed that CSA-13 stimulates cells to produce their own antimicrobial proteins.
New research led by the University of Leicester and published this week in the British Journal of Psychiatry reveals that people with mental health problems are receiving inferior care for their medical needs.
Children are especially vulnerable in the hospital and they are the population at highest risk of a medication error, according to the American Academy of Pediatrics. Meeting their needs in this environment can be especially challenging. The Joint Commission and Joint Commission Res (JCR) "Pediatric Conference: Safe Care, Quality Care, We Care" will help health care organizations review current pediatric emergency and perioperative services as benchmarks to improve their organizational approaches. JCR is a not-for-profit affiliate of The Joint Commission.
Australia"s regenerative medicine company, Mesoblast Limited (ASX:MSB)(PINK:MBLTY), announced positive three-month interim efficacy results from the first 20 patients enrolled in the Phase 2 heart failure trial of the proprietary allogeneic, or "off-the-shelf", adult stem cell product Revascor(TM).
Metal-on-metal hip replacement and resurfacing have become the most commonly used type of procedure in the United Kingdom for patients who are Read the full text article.
Published recently is a study investigating the use of percutaneous vertebroplasty as a treatment for osteoporotic compression fractures. Vertebral compression fractures are a common complication of osteoporosis and can cause extreme pain and limit movement. Type-II fractures are often resistant to non-operative treatments and therefore the authors wanted to investigate percutaneous vertebroplasty as a pain management technique in these cases.
Hip resurfacing can be a good alternative to total hip replacement (THR) in young adults because it conserves bone and it has acceptable short- to medium-term results. However, there have been concerns about fractures of the femoral neck with this procedure, partly due to notching and varus alignment during implantation.
Scientists at the Institute for Research in Immunology and Cancer (IRIC) of the Universitç© de Montrç©al have discovered a key mechanism used by cells to efficiently distribute chromosomes to new cells during cell multiplication. Published in the journal Molecular Cell, the study is the first to demonstrate that this mechanism relies on the polo kinase, an enzyme implicated in several cancers. Inhibiting this mechanism could be key to developing effective therapies to treat cancer.
A national public health campaign in France was associated with a marked
Danish children who move frequently appear to have an increased risk of attempted or completed suicide between ages 11 and 17, according to a report in the June issue of Archives of General Psychiatry, one of the JAMA/Archives journals.
Cellulitis and cellulite are two completely different things. Cellulitis is a bacterial infection of the dermis - the deep layer of skin - as well as the subcutaneous tissues (fat and soft tissue layer) that are under the skin. While cellulite is caused by fatty deposits under the skin that give it an orange peel or cottage cheese look. This article is about the bacterial infection - cellulitis.
Your immune system plays an important function in your health - it protects you against viruses, bacteria, and other toxins that can cause disease. In autoinflammatory diseases, however, the immune system goes awry, causing unprovoked and dangerous inflammation. Now, researchers from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health, and other institutions have discovered a new autoinflammatory syndrome, a rare genetic condition that affects children around the time of birth. The findings appear in the current issue of the New England Journal of Medicine.
Children who join gangs feel safer despite a greater risk of being assaulted or killed, according to federally funded research led by a Michigan State University criminologist.
By applying cutting-edge techniques in single-molecule manipulation, researchers at Harvard University have uncovered a fundamental feedback mechanism that the body uses to regulate the clotting of blood. The finding, which could lead to a new physical, quantitative, and predictive model of how the body works to respond to injury, has implications for the treatment of bleeding disorders.
ACCESS PHARMACEUTICALS, INC. (OTC Bulletin Board: ACCP), announced that new Thiarabine preclinical efficacy data will shortly be published demonstrating that thiarabine combined with clofarabine provides much greater antitumor activity than achieved by either agent alone. In one colorectal cancer model, 66% of mice were cured of their tumors. The publication which will appear in the journal "Cancer Chemotherapy and Pharmacology," was based on work conducted by Access" collaborators at the Southern Research Institute. The paper is entitled "Enhancement of the in vivo antitumor activity of clofarabine by 1-beta-D-[4-thio-arabinofuranosyl]-cytosine" (thiarabine).